{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:22:03Z","timestamp":1792448523796,"version":"4.5.0"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antihistamines are among the most widely used medications in the world. Ebastine is an antihistaminic which is long-acting, second-generation, and selective H1-receptor inverse agonist. I report a twelve-year-and-six-month-old girl with temporary prolongation of the QTc interval caused by acute ebastine intoxication due to TikTok challenge. Initial electrocardiogram showed sinus arrhythmia (72 beats\/min) and prolongation of the QTc interval (QTc 482 milliseconds). Gastric lavage was performed. Intravenous fluid was administered, and activated charcoal (1 g\/kg\/per dose) was given. Electrocardiogram 9 h after drug ingestion showed sinus rhythm and normal QTc interval (QTc 414milliseconds). During follow-up, no electrocardiogram abnormalities were detected with electrocardiogram monitoring. She was discharged on day 2 without any complications. This case report is the first in the literature to show acute intoxication with ebastine due to challenge video on TikTok, which leads to a temporary prolongation of the QTc interval. Also, with this case report, I assert the fact that it is important to properly supervise the use of social media, such as TikTok and to review the content of TikTok videos.<\/jats:p>","DOI":"10.1017\/s1047951122003717","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T07:20:25Z","timestamp":1670397625000},"page":"1213-1216","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Temporary prolongation of the QT interval in acute ebastine intoxication due to challenge video on TikTok in a girl"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1394-935X","authenticated-orcid":false,"given":"Sadiye","family":"Sert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"S1047951122003717_ref12","first-page":"243","article-title":"Ebastine has no effect on QTc interval at doses up to 50 times the therapeutic dose [abstract 779]","volume":"57","author":"Gispert","year":"2002","journal-title":"Allergy"},{"key":"S1047951122003717_ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.0306-5251.2001.01345.x"},{"key":"S1047951122003717_ref8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2165\/00002018-200124020-00003","article-title":"Safety of antihistamines in children","volume":"24","author":"Ten Eick","year":"2001","journal-title":"Drug Saf"},{"key":"S1047951122003717_ref2","first-page":"73","article-title":"Ebastine in the light of CONGA recommendations for the development of third-generation antihistamines","volume":"2","author":"Rico","year":"2009","journal-title":"J Asthma Allergy"},{"key":"S1047951122003717_ref3","first-page":"1","article-title":"Dangers of the TikTok benadryl challenge","volume":"38","author":"Minhaj","year":"2021","journal-title":"Contemporary PEDS Journal"},{"key":"S1047951122003717_ref9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1159\/000237062","article-title":"Loratadine produces antihistamine activity without adverse CNS, ECG or cardiovascular effects in guinea-pigs. comparative studies with terfenadine and sedating antihistamines","volume":"107","author":"Hey","year":"1995","journal-title":"Int Arch Allergy Immunol"},{"key":"S1047951122003717_ref6","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/MOP.0000000000000989","article-title":"Tide pods and tiger king: health implications of trends taking over pediatric populations","volume":"33","author":"Kriegel","year":"2021","journal-title":"Current opinion in paediatrics"},{"key":"S1047951122003717_ref7","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2022.2051536"},{"key":"S1047951122003717_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14602"},{"key":"S1047951122003717_ref16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ccr3.845","article-title":"Ebastine overdose in a child","volume":"5","author":"Pecoraro","year":"2017","journal-title":"Clinical Case Reports"},{"key":"S1047951122003717_ref5","article-title":"Investigating community evolutions in TikTok dangerous and non-dangerous challenges","volume":"0","author":"Bonifazi","year":"2022","journal-title":"J Inf Sci"},{"key":"S1047951122003717_ref14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00045391-199805000-00005","article-title":"Pharmacokinetics and electrocardiographic effect of ebastine in young versus elderly healthy subjects","volume":"5","author":"Huang","year":"1998","journal-title":"Am J Ther"},{"key":"S1047951122003717_ref10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2165\/00002018-199921001-00006","article-title":"Effects of H1 antihistamines on animal models of QTc prolongation","volume":"21","author":"Gras","year":"1999","journal-title":"Drug Saf"},{"key":"S1047951122003717_ref1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.paed.2016.02.006","article-title":"The use of antihistamines in children","volume":"26","author":"Anagnostou","year":"2016","journal-title":"Paediatr Child Health"},{"key":"S1047951122003717_ref13","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199921001-00009"},{"key":"S1047951122003717_ref4","doi-asserted-by":"publisher","DOI":"10.2196\/34050"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951122003717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T13:14:33Z","timestamp":1694783673000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951122003717\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,7]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S1047951122003717"],"URL":"https:\/\/doi.org\/10.1017\/s1047951122003717","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,7]]},"assertion":[{"value":"\u00a9 The Author(s), 2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}