{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:08:54Z","timestamp":1792422534395,"version":"4.5.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exertional syncope has been suggested to correlate with a cardiac aetiology, particularly when occurring in mid-stride. The aim of the study is to evaluate the incidence of cardiac disease among children presenting with exertional syncope, determine the influence of timing within activity, and determine the utility of genetic testing and implantable event monitors in the evaluation of cardiac syncope. The patients \u226418 years old with exertional syncope who underwent exercise stress testing between 2008 and 2019 were retrospectively included. Patients were assessed to be in one of three groups: mid-exertion (mid-stride syncope), peri-exertion (syncope during activity but not moving), and post-exertion (within minutes of the activity). A total of 334 patients were included; 46 % were mid-exertion, 18 % were peri-exertion, and 36 % were post-exertion. Thirteen patients (3.8 %) were diagnosed with cardiac syncope; n = 9 (69 %) mid-exertion. Only mid-exertional syncope was significantly associated with a cardiac diagnosis (OR: 2.6). Cardiac diagnoses included inherited arrhythmia syndromes (n = 9), abnormal coronary origins (n = 2), and supraventricular tachycardia (n = 2). Only catecholaminergic polymorphic ventricular tachycardia (n = 5) was associated with mid-exertional syncope (OR: 1.4). The definitive diagnostic test was exercise testing (n = 8), echocardiogram (n = 2), genetic testing (n = 1), ambulatory monitor (n = 1), and EKG (n = 1). Mid-stride syncope was more likely to result in a cardiac diagnosis, and exercise testing is the most common definitive test as catecholaminergic polymorphic ventricular tachycardia was the primary aetiology of exertional syncope in our cohort. Implantable event monitors and genetic testing could be helpful in ruling out cardiac disease.<\/jats:p>","DOI":"10.1017\/s1047951122004036","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T09:01:11Z","timestamp":1672995671000},"page":"2190-2195","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of paediatric exertional or peri-exertional syncope: does the story matter?"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8285-0567","authenticated-orcid":false,"given":"Ozlem","family":"Turan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Runciman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"von Alvensleben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn K.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"S1047951122004036_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951112000303"},{"key":"S1047951122004036_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115001481"},{"key":"S1047951122004036_ref11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.1.89"},{"key":"S1047951122004036_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2020.05.004"},{"key":"S1047951122004036_ref12","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/chd.12324","article-title":"Syncope best practices: a syncope clinical practice guideline to improve quality","volume":"11","author":"Zhang","year":"2016","journal-title":"Congenit Heart Dis"},{"key":"S1047951122004036_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv311"},{"key":"S1047951122004036_ref18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.1.46"},{"key":"S1047951122004036_ref6","doi-asserted-by":"publisher","DOI":"10.1177\/0009922819885660"},{"key":"S1047951122004036_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000002149"},{"key":"S1047951122004036_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.015"},{"key":"S1047951122004036_ref8","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1093\/eurheartj\/ehp298","article-title":"Guidelines for the diagnosis and management of syncope: the task force for the diagnosis and man agement of syncope of the European Society of Cardiology (ESC)","volume":"30","author":"Moya","year":"2009","journal-title":"Eur Heart J"},{"key":"S1047951122004036_ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.170274"},{"key":"S1047951122004036_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012213432507"},{"key":"S1047951122004036_ref16","first-page":"505","article-title":"Genetic testing in inherited heart diseases heart lung","volume":"29","author":"Ingles","year":"2020","journal-title":"Circulation"},{"key":"S1047951122004036_ref14","first-page":"e60","article-title":"ACC\/AHA\/HRS guideline for the evaluation and management of patients with syncope 1","volume":"136","author":"Shen","year":"2017","journal-title":"Circulation"},{"key":"S1047951122004036_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup101"},{"key":"S1047951122004036_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12324"},{"key":"S1047951122004036_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70113-9"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951122004036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T09:35:07Z","timestamp":1711445707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951122004036\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,6]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S1047951122004036"],"URL":"https:\/\/doi.org\/10.1017\/s1047951122004036","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,6]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. 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