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Association of congenitally corrected transposition of great arteries and isolated atrial septal defect is a very rare condition, and management of this association is challenging. In this paper, we describe three patients with congenitally corrected transposition of great arteries and isolated atrial septal defect who were admitted to our clinic and all of them underwent percutaneous closure of defect. From 2017 to 2020, we visited three patients with congenitally corrected transposition of great arteries and isolated atrial septal defect. Our patients\u2019 ages ranged from 28 to 38 years. All of them underwent percutaneous atrial septal defect device closure without any complications. Patients were discharged from hospital in good condition with a daily dose of Aspirin 80 mg and Plavix 75 mg. For all of them, follow-up echocardiography was performed the day after the procedure at 1, 3, and 6 months later and showed the function of the right-sided left ventricle improvement and the severity of the mitral regurgitation was reduced. Furthermore, clinical evaluation also indicated functional class improvement. Although the cases of percutaneous transcatheter closure are few and cannot be regarded as strong evidence to recommend this procedure, the outcomes are promising and can demonstrate that this approach is practical.<\/jats:p>","DOI":"10.1017\/s1047951123000070","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T07:53:38Z","timestamp":1676274818000},"page":"1479-1486","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Percutaneous closure of an atrial septal defect in adult patients with congenitally corrected transposition of the great arteries"],"prefix":"10.1017","volume":"33","author":[{"given":"Zahra","family":"Khajali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0824-1901","authenticated-orcid":false,"given":"Amin","family":"Sayyadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atta","family":"Firouzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3004-2071","authenticated-orcid":false,"given":"Maryam","family":"Aliramezany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"S1047951123000070_ref17","volume-title":"Seminars in Thoracic and Cardiovascular Surgery: Pediatric Cardiac Surgery 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