{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:29:45Z","timestamp":1777526985896,"version":"3.51.4"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951123000215_as1\"><jats:title>Objective:<\/jats:title><jats:p>To perform a statewide characteristics and outcomes analysis of the Trisomy 18 (T18) population and explore the potential impact of associated congenital heart disease (CHD) and congenital heart surgery.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123000215_as2\"><jats:title>Study Design:<\/jats:title><jats:p>Retrospective review of the Texas Hospital Inpatient Discharge Public Use Data File between 2009 and 2019, analysing discharges of patients with T18 identified using ICD-9\/10 codes. Discharges were linked to analyse patients. Demographic characteristics and available outcomes were evaluated. The population was divided into groups for comparison: patients with no documentation of CHD (<jats:italic>T18NoCHD<\/jats:italic>), patients with CHD without congenital heart surgery (<jats:italic>T18CHD<\/jats:italic>), and patients who underwent congenital heart surgery (<jats:italic>T18CHS<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123000215_as3\"><jats:title>Results:<\/jats:title><jats:p>One thousand one hundred fifty-six eligible patients were identified: 443 (38%) <jats:italic>T18NoCHD<\/jats:italic>, 669 (58%) <jats:italic>T18CHD<\/jats:italic>, and 44 (4%) <jats:italic>T18CHS<\/jats:italic>. <jats:italic>T18CHS<\/jats:italic> had a lower proportion of Hispanic patients (n = 9 (20.45%)) compared to <jats:italic>T18CHD<\/jats:italic> (n = 315 (47.09%)), and <jats:italic>T18NoCHD<\/jats:italic> (n = 219 (49.44%)) (p &lt; 0.001 for both). Patients with Medicare\/Medicaid insurance had a 0.42 odds ratio (95%CI: 0.20\u20130.86, p = 0.020) of undergoing congenital heart surgery compared to private insurance. <jats:italic>T18CHS<\/jats:italic> had a higher median total days in-hospital (47.5 [IQR: 12.25\u2013113.25] vs. 9 [IQR: 3\u201324] and 2 [IQR: 1\u20135], p &lt; 0.001); and a higher median number of admissions (n = 2 [IQR: 1\u20134]) vs. 1 [IQR: 1\u20132] and 1 [IQR: 1\u20131], (p &lt; 0.001 for both). However, the post-operative median number of admissions for <jats:italic>T18CHS<\/jats:italic> was 0 [IQR: 0\u20132]. After the first month of life, <jats:italic>T18CHS<\/jats:italic> had freedom from in-hospital mortality similar to <jats:italic>T18NoCHD<\/jats:italic> and superior to <jats:italic>T18CHD<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123000215_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Short-term outcomes for <jats:italic>T18CHS<\/jats:italic> patients are encouraging, suggesting a freedom from in-hospital mortality that resembles the <jats:italic>T18NoCHD<\/jats:italic>. The highlighted socio-economic differences between the groups warrant further investigation. Development of a prospective registry for T18 patients should be a priority for better understanding of longer-term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951123000215","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T07:53:36Z","timestamp":1676274816000},"page":"2328-2333","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Trisomy 18: disparities of care and outcomes in the State of Texas between 2009 and 2019"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2501-3855","authenticated-orcid":false,"given":"Michelle","family":"Mizrahi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0725-2791","authenticated-orcid":false,"given":"Andrew","family":"Well","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin A.","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Lucke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles D.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos M.","family":"Mery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziv","family":"Beckerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"S1047951123000215_ref14","doi-asserted-by":"publisher","DOI":"10.1542\/neo.21-4-e217"},{"key":"S1047951123000215_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31512"},{"key":"S1047951123000215_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.02.068"},{"key":"S1047951123000215_ref11","unstructured":"11. Texas Hospital Inpatient Discharge Public Use Data File, [1st quarter 2009\u20134th quarter 2019]. Texas Department of State Health Services, Center for Health Statistics, Austin, Texas, December 2020."},{"key":"S1047951123000215_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31527"},{"key":"S1047951123000215_ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-81"},{"key":"S1047951123000215_ref12","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2020.06.037"},{"key":"S1047951123000215_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61365"},{"key":"S1047951123000215_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-019-03531-4"},{"key":"S1047951123000215_ref4","doi-asserted-by":"publisher","DOI":"10.3390\/genes11121466"},{"key":"S1047951123000215_ref5","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012349"},{"key":"S1047951123000215_ref10","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55070352"},{"key":"S1047951123000215_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-2032-3"},{"key":"S1047951123000215_ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-0772"},{"key":"S1047951123000215_ref13","volume-title":"R: A Language and Environment for Statistical Computing","year":"2019"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951123000215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T09:36:05Z","timestamp":1711445765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951123000215\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,13]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S1047951123000215"],"URL":"https:\/\/doi.org\/10.1017\/s1047951123000215","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,13]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}