{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:04:48Z","timestamp":1770059088764,"version":"3.49.0"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951123000756_as1\"><jats:title>Introduction:<\/jats:title><jats:p>The decision to close small ventricular septal defect is still controversial. Previous study showed that ventricular dysfunction in adulthood is correlated with small perimembranous ventricular septal defect. N terminal pro B-type natriuretic peptide (NT-proBNP) is a neurohormone secreted primarily from the ventricles in response to increased left and right ventricular pressure and volume load. The left ventricular end-diastolic pressure will reflect ventricular performance. This study aimed to evaluate the correlation between left ventricular end-diastolic pressure and the NT-proBNP in children with small perimembranous ventricular septal defect.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123000756_as2\"><jats:title>Materials and Methods:<\/jats:title><jats:p>Level of NT-proBNP in 41 patients with small perimembranous ventricular septal defect was measured before transcatheter closure procedure. We also measured the left ventricular end-diastolic pressure in each patients during catheterisation. We investigated the value of NT-proBNP in patients with small perimembranous ventricular septal defect and its correlation with the level of left ventricular end-diastolic pressure<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123000756_as3\"><jats:title>Result:<\/jats:title><jats:p>We found positive correlation between NT-proBNP and left ventricular end-diastolic pressure (r = 0.278, p = 0.046). The median of NT-proBNP at left ventricular end-diastolic pressure &lt; 10 was lower than at left ventricular end-diastolic pressure \u2265 10 (0.87 ng\/ml versus 1.83 ng\/ml, p = 0.023). The results of the NT-proBNP diagnostic test for predicting left ventricular end-diastolic pressure \u2265 10 using Receiver Operating Characteristic (ROC) analysis showed the area under the curve value of 0.715 (95% CI: 0.546\u20130.849). The cut-off value &gt;0.99 ng\/ml of NT-proBNP has 75.0% sensitivity and 72.2% specifity.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123000756_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Level of NT-proBNP higher than 0.99 ng\/ml was correlated significantly with left ventricular end-diastolic pressure \u226510 in children with small perimembranous ventricular septal defect.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951123000756","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T07:25:51Z","timestamp":1681975551000},"page":"2604-2609","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["NT-proBNP levels as a predictor of higher left ventricular end-diastolic pressure in children with small perimembranous ventricular septal defect"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1852-6986","authenticated-orcid":false,"given":"Putria R.","family":"Apandi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mulyadi M.","family":"Djer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahmat B.","family":"Kuswiyanto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elrika A.","family":"Wijaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bagus","family":"Artiko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1396-5285","authenticated-orcid":false,"given":"Sri E.","family":"Rahayuningsih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"S1047951123000756_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.09.047"},{"key":"S1047951123000756_ref1","first-page":"713","volume-title":"Moss and Adam\u2019s heart disease in infant, children, and adolescent","author":"Lewin","year":"2013"},{"key":"S1047951123000756_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/BF00798207"},{"key":"S1047951123000756_ref17","doi-asserted-by":"publisher","DOI":"10.4236\/wjcd.2018.87038"},{"key":"S1047951123000756_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2008.02642.x"},{"key":"S1047951123000756_ref20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008813"},{"key":"S1047951123000756_ref12","first-page":"124","volume-title":"Park\u2019s pediatric cardiology for practitioners","author":"Park","year":"2021"},{"key":"S1047951123000756_ref3","article-title":"Second natural history study of congenital heart defects. 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