{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:58:15Z","timestamp":1747173495503,"version":"3.40.5"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S104795112300077X_as1\"><jats:title>Introduction:<\/jats:title><jats:p>Coronary artery dilation associated with bicuspid\/unicuspid aortic valves is described in adults with limited data in children. We aimed to describe the clinical course of children with bicuspid\/unicuspid aortic valves and coronary dilation including coronary Z-score changes over time, association of coronary changes with aortic valve anatomy\/function, and complications.<\/jats:p><\/jats:sec><jats:sec id=\"S104795112300077X_as2\"><jats:title>Materials and methods:<\/jats:title><jats:p>Institutional databases were searched for children \u226418 years with both bicuspid\/unicuspid aortic valves and coronary dilation (1\/2006-6\/2021). Kawasaki disease and isolated supra-\/subvalvar aortic stenosis were excluded. Statistics were descriptive with associations measured by Fisher\u2019s exact test and overlapping 83.7% confidence intervals.<\/jats:p><\/jats:sec><jats:sec id=\"S104795112300077X_as3\"><jats:title>Results:<\/jats:title><jats:p>Of 17 children, bicuspid\/unicuspid aortic valve was diagnosed at birth in 14 (82%). Median age at coronary dilation diagnosis was 6.4 years (range: 0-17.0). Aortic stenosis was present in 14 (82%) [2 (14%) moderate, 8 (57%) severe]; 10 (59%) had aortic regurgitation; 8 (47%) had aortic dilation. The right coronary was dilated in 15 (88%), left main in 6 (35%), and left anterior descending in 1 (6%) with no relationship between leaflet fusion pattern or severity of aortic regurgitation\/stenosis on coronary Z-score. Follow-up evaluations were available for 11 (mean 9.3 years, range 1.1\u201314.8) with coronary Z-scores increasing in 9\/11 (82%). Aspirin was used in 10 (59%). There were no deaths or coronary artery thrombosis.<\/jats:p><\/jats:sec><jats:sec id=\"S104795112300077X_as4\"><jats:title>Discussion:<\/jats:title><jats:p>In children with bicuspid\/unicuspid aortic valves and coronary dilation, the right coronary artery was most frequently involved. Coronary dilation was observed in early childhood and frequently progressed. Antiplatelet medication use was inconsistent, but no child died nor developed thrombosis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s104795112300077x","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T07:25:07Z","timestamp":1681975507000},"page":"2610-2615","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Coronary artery dilation associated with bicuspid and unicuspid aortic valve disease in children: a series of 17 patients"],"prefix":"10.1017","volume":"33","author":[{"given":"David L.","family":"Robinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. LuAnn","family":"Minich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaji C.","family":"Menon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhining","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6436-7504","authenticated-orcid":false,"given":"Aaron W.","family":"Eckhauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3990-5734","authenticated-orcid":false,"given":"Adam L.","family":"Ware","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"S104795112300077X_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/9781118742440.ch5"},{"key":"S104795112300077X_ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.004092"},{"key":"S104795112300077X_ref12","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jacc.2020.11.035","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American heart association joint committee on clinical practice guidelines","volume":"77","author":"Members","year":"2021","journal-title":"J Am Coll Cardiol."},{"key":"S104795112300077X_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14885"},{"key":"S104795112300077X_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12591"},{"key":"S104795112300077X_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(01)00365-5"},{"key":"S104795112300077X_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.027"},{"key":"S104795112300077X_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2021.05.008"},{"key":"S104795112300077X_ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.119.009717"},{"key":"S104795112300077X_ref11","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000484"},{"key":"S104795112300077X_ref22","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000087660.82721.15"},{"key":"S104795112300077X_ref17","unstructured":"17. 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}