{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:38:26Z","timestamp":1793813906221,"version":"4.6.1"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951123000793_as1\"><jats:title>Background:<\/jats:title><jats:p>Multisystem inflammatory syndrome in children is a rare, post-infectious complication of SARS-CoV-2 infection in children. We aimed to assess the long-term sequelae, particularly cardiac, in a large, diverse population.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123000793_as2\"><jats:title>Methods:<\/jats:title><jats:p>We performed a retrospective cohort study of all children (aged 0\u201320 years, n = 304) admitted to a tertiary care centre with a diagnosis of multisystem inflammatory syndrome in children from March 1, 2020 to August 31, 2021 and had at least one follow-up visit through December 31, 2021. Data were collected at hospitalisation, 2 weeks, 6 weeks, 3 months, and 1 year after diagnosis, where applicable. Cardiovascular outcomes included left ventricular ejection fraction, presence or absence of pericardial effusion, coronary artery abnormalities, and abnormal electrocardiogram findings.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123000793_as3\"><jats:title>Results:<\/jats:title><jats:p>Population was median age 9 years (IQR 5\u201312), 62.2% male, 61.8% African American (AA), and 15.8% Hispanic. Hospitalisation findings included abnormal echocardiogram 57.2%, mean worst recorded left ventricular ejection fraction 52.4% \u00b1 12.4%, non-trivial pericardial effusion 13.4%, coronary artery abnormalities 10.6%, and abnormal ECG 19.6%. During follow-up, abnormal echocardiogram significantly decreased to 6.0% at 2 weeks and 4.7% at 6 weeks. Mean left ventricular ejection fraction significantly increased to 65.4% \u00b1 5.6% at 2 weeks and stabilised. Pericardial effusion significantly decreased to 3.2% at 2 weeks and stabilised. Coronary artery abnormalities significantly decreased to 2.0% and abnormal electrocardiograms significantly decreased to 6.4% at 2 weeks and stabilised.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123000793_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Children with multisystem inflammatory syndrome in children have significant echocardiographic abnormalities during the acute presentation, but these findings typically improve within weeks. However, a small subset of patients may have persistent coronary abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951123000793","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T06:34:15Z","timestamp":1682663655000},"page":"2632-2638","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Six-month cardiac outcomes in children with multisystem inflammatory syndrome in children"],"prefix":"10.1017","volume":"33","author":[{"given":"Joshua","family":"Kaltman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohali","family":"Keesari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Madani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Jaggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2243-8367","authenticated-orcid":false,"given":"Matthew E.","family":"Oster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"S1047951123000793_ref19","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951122004140"},{"key":"S1047951123000793_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"S1047951123000793_ref14","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-050973"},{"key":"S1047951123000793_ref7","first-page":"e0203251","article-title":"Longitudinal assessment of cardiac outcomes of multisystem inflammatory syndrome in children associated with COVID-19 infections","volume":"10","author":"Matsubara","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"S1047951123000793_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2021.0630"},{"key":"S1047951123000793_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-022-02907-y"},{"key":"S1047951123000793_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00050-X"},{"key":"S1047951123000793_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2022.02.049"},{"key":"S1047951123000793_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00138-3"},{"key":"S1047951123000793_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.12.033"},{"key":"S1047951123000793_ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021756"},{"key":"S1047951123000793_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.case.2021.08.002"},{"key":"S1047951123000793_ref2","unstructured":"2. National Center for Immunization and Respiratory Diseases (U.S.). Health department-reported cases of multisystem inflammatory syndrome in children (MIS-c) in the United States. Centers for disease control and prevention, 2021. https:\/\/www.cdc.gov\/mis-c\/cases\/index.html."},{"key":"S1047951123000793_ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000484"},{"key":"S1047951123000793_ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.820229"},{"key":"S1047951123000793_ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048360"},{"key":"S1047951123000793_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.08.003"},{"key":"S1047951123000793_ref22","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000003094"},{"key":"S1047951123000793_ref3","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6932e2"},{"key":"S1047951123000793_ref17","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.024393"},{"key":"S1047951123000793_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10369"},{"key":"S1047951123000793_ref8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-051155"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951123000793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T01:32:22Z","timestamp":1702431142000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951123000793\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,28]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S1047951123000793"],"URL":"https:\/\/doi.org\/10.1017\/s1047951123000793","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,28]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. 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