{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:37:24Z","timestamp":1792697844344,"version":"4.5.0"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S104795112300121X_as1\"><jats:title>Objectives:<\/jats:title><jats:p>To define the incidence of definitive necrotising enterocolitis in term infants with CHD and identify risk factors for morbidity\/mortality.<\/jats:p><\/jats:sec><jats:sec id=\"S104795112300121X_as2\"><jats:title>Methods:<\/jats:title><jats:p>We performed a 20-year (2000\u20132020) single-institution retrospective cohort study of term infants with CHD admitted to the Boston Children\u2019s Hospital cardiac ICU with necrotising enterocolitis (Bell\u2019s stage \u2265 II). The primary outcome was a composite of in-hospital mortality and post-necrotising enterocolitis morbidity (need for extracorporeal membrane oxygenation, multisystem organ failure based on the paediatric sequential organ failure assessment score, and\/or need for acute gastrointestinal intervention). Predictors included patient characteristics, cardiac diagnosis\/interventions, feeding regimen, and severity measures.<\/jats:p><\/jats:sec><jats:sec id=\"S104795112300121X_as3\"><jats:title>Results:<\/jats:title><jats:p>Of 3933 term infants with CHD, 2.1% (n = 82) developed necrotising enterocolitis, with 67% diagnosed post-cardiac intervention. Thirty (37%) met criteria for the primary outcome. In-hospital mortality occurred in 14 infants (17%), of which nine (11%) deaths were attributable to necrotising enterocolitis. Independent predictors of the primary outcome included moderate to severe systolic ventricular dysfunction (odds ratio 13.4,confidence intervals 1.13\u2013159) and central line infections pre-necrotising enterocolitis diagnosis (odds ratio 17.7, confidence intervals 3.21\u201397.0) and mechanical ventilation post-necrotising enterocolitis diagnosis (odds ratio 13.5, confidence intervals 3.34\u201354.4). Single ventricle, ductal dependency, and feeding related factors were not independently associated with the primary outcome.<\/jats:p><\/jats:sec><jats:sec id=\"S104795112300121X_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>The incidence of necrotising enterocolitis was 2.1% in term infants with CHD. Adverse outcomes occurred in greater than 30% of patients. Presence of systolic dysfunction and central line infections prior to diagnosis and need for mechanical ventilation after diagnosis of necrotising enterocolitis can inform risk triage and prognostic counseling for families.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s104795112300121x","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T07:21:54Z","timestamp":1684999314000},"page":"92-100","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Risk Factors for Adverse Outcomes in Term Infants with CHD and Definitive Necrotising Enterocolitis"],"prefix":"10.1017","volume":"34","author":[{"given":"Anna 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