{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:38:15Z","timestamp":1781325495560,"version":"3.54.1"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951123001348_as1\"><jats:title>Objective:<\/jats:title><jats:p>This study aimed to evaluate the cardiovascular manifestations and surveillance of multisystem inflammatory syndrome in children\u00a0(MIS-C) and to determine the correlation of echocardiographic findings with cardiac magnetic resonance imaging findings.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123001348_as2\"><jats:title>Methods:<\/jats:title><jats:p>Forty-four children diagnosed as MIS-C with cardiac involvement were enrolled in this observational descriptive study. The diagnosis of MIS-C was made according to the criteria of Centers for Disease Control and Prevention. Clinical findings, laboratory parameters, and electrocardiographic and echocardiographic findings at the time of diagnosis and during follow-up were evaluated. Cardiac magnetic resonance was performed on 28 (64%) cases. The 1-year follow-up imaging was performed in all cases with abnormal initial cardiac magnetic resonance findings.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123001348_as3\"><jats:title>Results:<\/jats:title><jats:p>Forty-four patients (56.8% male) with a mean age of 8.5 \u00b1 4.8 years were enrolled in this study. There was a significant positive correlation between high-sensitivity cardiac troponin T (mean: 162 \u00b1 444.4 pg\/ml) and N-terminal pro\u00a0b-type natriuretic peptide (mean: 10,054 \u00b1 11,604 pg\/ml) (p &lt; 0.01). Number of cases with an electrocardiographic and echocardiographic abnormality was 34 (77%) and 31 (70%), respectively. Twelve cases (45%) had left ventricular systolic dysfunction and 14 (32%) cases had pericardial effusion on admission. Three cases (11%) had cardiac magnetic resonance findings that may be attributed to the presence of myocardial inflammation, and pericardial effusion was present in seven (25%) cases. Follow-up cardiac magnetic resonances of all cases were normal. Cardiac abnormalities were completely resolved in all except two cases.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123001348_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Myocardial involvement can be seen during acute disease, but MIS-C generally does not lead to prominent damage during a year of surveillance. Cardiac magnetic resonance is a valuable tool to evaluate the degree of myocardial involvement in cases with MIS-C.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951123001348","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T08:18:04Z","timestamp":1688026684000},"page":"291-300","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Cardiovascular manifestations and cardiac magnetic resonance follow-up of multisystem inflammatory syndrome in children (MIS-C)"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9542-1937","authenticated-orcid":false,"given":"Selen","family":"Karag\u00f6zl\u00fc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-0685","authenticated-orcid":false,"given":"Mehmet G.","family":"Ramo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3298-5567","authenticated-orcid":false,"given":"\u00d6zlem","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeyhun","family":"Bakhtiyarzada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alperen","family":"Ayd\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Mustafa","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3945-3384","authenticated-orcid":false,"given":"Beg\u00fcm","family":"Murt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersin","family":"\u00d6zkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice Belk\u0131s","family":"\u0130nceli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anar","family":"Gurbanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u0131lmaz","family":"\u015e\u00fckriye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berrin","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"\u00d6zdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ergin","family":"\u00c7ift\u00e7i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan\u0131l","family":"Kendirli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayfun","family":"U\u00e7ar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer Suat","family":"Fitoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0795-0810","authenticated-orcid":false,"given":"Ercan","family":"Tutar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"key":"S1047951123001348_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26166"},{"key":"S1047951123001348_ref28","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeaa212"},{"key":"S1047951123001348_ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-022-02927-8"},{"key":"S1047951123001348_ref3","doi-asserted-by":"crossref","first-page":"422","DOI":"10.15585\/mmwr.mm6914e4","article-title":"Coronavirus disease 2019 in children\u2014United States, February 12\u2013April 2, 2020","volume":"69","author":"Covid","year":"2020","journal-title":"Morb Mort Week Rep"},{"key":"S1047951123001348_ref32","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeac096"},{"key":"S1047951123001348_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.01.035"},{"key":"S1047951123001348_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-022-04748-6"},{"key":"S1047951123001348_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.10.004"},{"key":"S1047951123001348_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.034"},{"key":"S1047951123001348_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s40124-021-00258-5"},{"key":"S1047951123001348_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.03.026"},{"key":"S1047951123001348_ref14","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2020.5.46714"},{"key":"S1047951123001348_ref4","unstructured":"4. 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World Health Organization., Multisystem Inflammatory Syndrome in Children and Adolescents with COVID-19: Scientific Brief, 2020, World Health Organization. https:\/\/apps.who.int\/iris\/handle\/10665\/332095,"},{"key":"S1047951123001348_ref24","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10369"},{"key":"S1047951123001348_ref7","doi-asserted-by":"publisher","DOI":"10.3345\/cep.2020.01900"},{"key":"S1047951123001348_ref9","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020202288"},{"key":"S1047951123001348_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2003.12.005"},{"key":"S1047951123001348_ref12","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951123001348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:09:42Z","timestamp":1708474182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951123001348\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,29]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S1047951123001348"],"URL":"https:\/\/doi.org\/10.1017\/s1047951123001348","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,29]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}