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The intravenous infusion is well established in loading infusion and maintenance with an onset of action of 30 minutes until 2 hours or even more. Our aim is to report three patients with pulmonary atresia that presented hypercyanotic spell due to a ductal spasm during cardiac catheterisation in whom the administration of a bolus of alprostadil reversed the spasm and increased pulmonary flow, immediately stabilising the condition of the patients allowing subsequent successful stent placement with no serious complications or sequelae after the administration of the bolus. More studies are needed to make a recommendation regarding the use of alprostadil in bolus in cases where the ductal spasm might jeopardise the life of the patient.<\/jats:p>","DOI":"10.1017\/s1047951123001403","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T09:30:36Z","timestamp":1688549436000},"page":"314-318","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Intravenous prostaglandin E1 (alprostadil) bolus in ductus arteriosus-dependent CHD: valid or absolutely contraindicated?"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5076-8603","authenticated-orcid":false,"given":"Jose L.","family":"Col\u00edn Ortiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0116-9532","authenticated-orcid":false,"given":"Angel","family":"Cruz Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4236-8642","authenticated-orcid":false,"given":"Jorge A.","family":"Silva Estrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Maldonado Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Corona Villalobos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gonz\u00e1lez Rebeles Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda F.","family":"P\u00e9rez P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"S1047951123001403_ref3","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.11-1086"},{"key":"S1047951123001403_ref7","first-page":"233","article-title":"Physical compatibility of alprostadil with commonly used IV solutions and medications in the neonatal intensive care unit","volume":"11","author":"Dice","year":"2006","journal-title":"J Pediatr Pharmacol Ther"},{"key":"S1047951123001403_ref2","first-page":"1","article-title":"The prostaglandins. A family of biologically-active lipids","volume":"20","author":"Bergstr\u00f6m","year":"1948","journal-title":"Pharmacol Rev"},{"key":"S1047951123001403_ref5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.64.5.893"},{"key":"S1047951123001403_ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.64.5.899"},{"key":"S1047951123001403_ref6","volume-title":"Prostaglandinas","author":"Palomares","year":"2013"},{"key":"S1047951123001403_ref1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1936.sp003433"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951123001403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:09:46Z","timestamp":1708474186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951123001403\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,5]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S1047951123001403"],"URL":"https:\/\/doi.org\/10.1017\/s1047951123001403","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,5]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. 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