{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:58:22Z","timestamp":1747173502245,"version":"3.40.5"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951123001440_as1\"><jats:title>Background:<\/jats:title><jats:p>Lifetime radiation exposure for paediatric orthotopic heart transplant (OHT) patients is significant with cardiac catheterisation as the dominant source. Interventional cardiac magnetic resonance is utilised to obtain simultaneous, radiation-free haemodynamics and flow\/function measurements. We sought to compare invasive haemodynamic measurements and radiation exposure in traditional cardiac catheterisation, to comprehensive interventional cardiac magnetic resonance.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123001440_as2\"><jats:title>Methods:<\/jats:title><jats:p>Twenty-eight OHT patients who underwent 67 interventional cardiac magnetic resonance procedures at Children\u2019s National Hospital were identified. Both invasive oximetry with peripheral oxygen saturation (Fick) and cardiac magnetic resonance phase contrast measurements of pulmonary and systemic blood flow were performed. Systemic and pulmonary blood flow from the two modalities was compared using Bland\u2013Altman, concordance analysis, and inter-reader correlation. A mixed model was implemented to account for confounding variables and repeat encounters. Radiation dosage data were collected for a contemporaneous cohort of orthotopic heart transplant patients undergoing standard, X-ray-guided catheterisation.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123001440_as3\"><jats:title>Results:<\/jats:title><jats:p>Simultaneous cardiac magnetic resonance and Fick have poor agreement in our study based on Lin\u2019s correlation coefficient of 0.68 and 0.73 for pulmonary and systemic blood flow, respectively. Bland\u2013Altman analysis demonstrated a consistent over estimation of cardiac magnetic resonance cardiac output by Fick. The average indexed dose area product for patients undergoing haemodynamics with endomyocardial biopsy was 0.73 (SD \u00b10.6) Gy*m<jats:sup>2<\/jats:sup>\/kg. With coronary angiography added, the indexed dose area product was 14.6 (SD \u00b1 7.8) Gy*m<jats:sup>2<\/jats:sup>\/kg.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123001440_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Cardiac magnetic resonancemeasurements of cardiac output\/index in paediatric orthotopic heart transplant patients have poor concordance with Fick estimates; however, cardiac magnetic resonance has good internal validity and inter-reader reliability. Radiation doses are small for haemodynamics with biopsy and increase exponentially with angiography, identifying a new target for cardiac magnetic resonance imaging.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951123001440","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T06:59:30Z","timestamp":1686812370000},"page":"262-267","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac magnetic resonance haemodynamics in paediatric heart transplant patients: fick oximetry versus cardiac magnetic resonance phase contrast"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9112-7618","authenticated-orcid":false,"given":"Jennifer","family":"Schramm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ileen","family":"Cronin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"McCarter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason 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