{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T03:28:42Z","timestamp":1767151722460,"version":"build-2238731810"},"reference-count":9,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S104795112300152X_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Up to 90% of adults with untreated atrial septal defect will be symptomatic by 4\n                      <jats:sup>th<\/jats:sup>\n                      decade, and 30-49% will develop heart failure. 8\u201310% of these patients have pulmonary arterial hypertension with a female predominance regardless of age. We aimed to demonstrate that fenestrated closure can be safely performed in patients with decompensated heart failure and atrial septal defect-associated pulmonary arterial hypertension with improved outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S104795112300152X_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Transcatheter fenestrated atrial septal defect closures (Occlutech GmbH, Jena, Germany) were performed on a compassionate-use basis in 5 consecutive adult patients with atrial septal defect-associated pulmonary arterial hypertension and severe heart failure with prohibitive surgical mortality risks. Change in systemic oxygen saturation, 6-minute walk test, NYHA class, echocardiographic and haemodynamic parameters were used as parameters of outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S104795112300152X_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All patients were female, mean age 48.8 \u00b1 13.5 years, followed up for a median of 29 months (max 64 months). Significant improvements observed in the 6-minute walk test, and oxygen saturation comparing day 0 time point to all other follow-up time points data (\n                      <jats:italic>B<\/jats:italic>\n                      = 1.32, SE = 0.28,\n                      <jats:italic>t<\/jats:italic>\n                      (22.7) = -4.77,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0001); and in the haemodynamic data (including pulmonary vascular resistance and pulmonary pressure) (\n                      <jats:italic>B<\/jats:italic>\n                      = \u20130.60, SE = 0.22,\n                      <jats:italic>t<\/jats:italic>\n                      (40.2) = 2.74,\n                      <jats:italic>p<\/jats:italic>\n                      = .009). All patients showed improved right ventricular size and function along with NYHA class. There were no procedure-related complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S104795112300152X_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Fenestrated atrial septal defect closure is feasible in adults with decompensated heart failure and atrial septal defect-associated pulmonary arterial hypertension. It results in sustained haemodynamic and functional improvement<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s104795112300152x","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T05:34:11Z","timestamp":1689744851000},"page":"395-400","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Atrial septal defect-associated pulmonary hypertension with decompensated heart failure: outcomes after fenestrated device closure"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5851-3058","authenticated-orcid":false,"given":"Ahmed","family":"Deniwar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique O.","family":"Aregullin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana K.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2490-2562","authenticated-orcid":false,"given":"Michael T.","family":"Finn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J.","family":"Vettukattil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"S104795112300152X_ref4","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.077669"},{"key":"S104795112300152X_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.04.044"},{"key":"S104795112300152X_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.1029"},{"key":"S104795112300152X_ref7","first-page":"1","volume-title":"Congenital cardiology today:","volume":"15","author":"Samuel","year":"2017"},{"key":"S104795112300152X_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/1522-726X(200102)52:2<177::AID-CCD1043>3.0.CO;2-G"},{"key":"S104795112300152X_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.06.036"},{"key":"S104795112300152X_ref2","first-page":"498","article-title":"Partial closure with a self-made fenestrated device of secundum atrial septal defect with severe pulmonary artery hypertension in adults","volume":"18","author":"Tesorio","year":"2021","journal-title":"J Geriatr Cardiol"},{"key":"S104795112300152X_ref8","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY15M07_08"},{"key":"S104795112300152X_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.82.1.30"}],"updated-by":[{"DOI":"10.1017\/s1047951123003281","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000}}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S104795112300152X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T19:10:08Z","timestamp":1708456208000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S104795112300152X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,19]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S104795112300152X"],"URL":"https:\/\/doi.org\/10.1017\/s104795112300152x","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,19]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}