{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:46:52Z","timestamp":1783464412637,"version":"3.55.0"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951123001609_as1\"><jats:title>Objective:<\/jats:title><jats:p>To assess the impact of overweight and obesity in the second and third trimesters of pregnancy on fetal cardiac function parameters.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123001609_as2\"><jats:title>Methods:<\/jats:title><jats:p>We performed a prospective cohort study of 374 singleton pregnant women between 20w0d and 36w6d divided into three groups: 154 controls (body mass index - BMI &lt; 25 kg\/m<jats:sup>2<\/jats:sup>), 140 overweight (BMI 25\u201330 kg\/m<jats:sup>2<\/jats:sup>) and 80 obese (BMI \u2265 30 kg\/m<jats:sup>2<\/jats:sup>). Fetal left ventricular (LV) modified myocardial performance index (Mod-MPI) was calculated according to the following formula: (isovolumetric contraction time + isovolumetric relaxation time)\/ejection time. Spectral tissue Doppler was used to determine LV and right ventricular (RV) myocardial performance index (MPI'), peak myocardial velocity during systole (S'), early diastole (E'), and late diastole (A').<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123001609_as3\"><jats:title>Results:<\/jats:title><jats:p>We found significant differences between the groups in maternal age (p &lt; 0.001), maternal weight (p &lt; 0.001), BMI (p &lt; 0.001), number of pregnancies (p &lt; 0.001), parity (p &lt; 0.001), gestational age (p = 0.013), and estimated fetal weight (p = 0.003). Overweight pregnant women had higher LV Mod-MPI (0.046 versus 0.044 seconds, p = 0.009) and LV MPI' (0.50 versus 0.47 seconds, p &lt; 0.001) than the control group. Obese pregnant women had higher RV E' than control (6.82 versus 6.33 cm\/sec, p = 0.008) and overweight (6.82 versus 6.46 cm\/sec, p = 0.047) groups. There were no differences in 5-min APGAR score &lt; 7, neonatal intensive care unit admission, hypoglycemia and hyperglobulinemia between the groups.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123001609_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>We observed fetal myocardial dysfunction in overweight and obese pregnant women with higher LV Mod-MPI, LV MPI' and RV E' compared to fetuses from normal weight pregnant women.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951123001609","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T07:18:25Z","timestamp":1688627905000},"page":"319-324","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Impact of overweight and obesity in the fetal cardiac function parameters in the second and third trimesters of pregnancy"],"prefix":"10.1017","volume":"34","author":[{"given":"Alberto 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