{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:41:58Z","timestamp":1783712518794,"version":"3.55.0"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951123001774_as1\"><jats:title>Objective:<\/jats:title><jats:p>The aim of this study is to investigate the frequency of fragmented QRS and its associations with clinical findings and prognosis in children diagnosed with dilated cardiomyopathy with or without left ventricular non-compaction.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123001774_as2\"><jats:title>Methods:<\/jats:title><jats:p>This retrospective study was conducted between 2010 and 2020. Patients with dilated cardiomyopathy were classified into two groups according to the presence of left ventricular non-compaction: Dilated cardiomyopathy with left ventricular non-compaction and dilated cardiomyopathy without left ventricular non-compaction. Patients were also divided into two groups according to the presence of fragmented QRS (fragmented QRS group and non-fragmented QRS group).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123001774_as3\"><jats:title>Results:<\/jats:title><jats:p>Twenty-three of 44 patients (52.3%) were male. Among left ventricular non-compaction patients, the fragmented QRS group had more complex ventricular arrhythmias (p = 0.003). Patients with fragmented QRS had a significantly higher rate of major adverse cardiac events and\/or cardiac death in both cardiomyopathy groups (p = 0.003 and p = 0.005). However, the rate of major adverse cardiac events and\/or cardiac death was similar between dilated cardiomyopathy patients with and without left ventricular non-compaction. Multivariate logistic regression analysis showed that the presence of fragmented QRS strongly predicts major adverse cardiac events and\/or cardiac death (odds ratio, 31.186; 95% confidence interval, 2.347\u2013414.307). Although the survival rates between cardiomyopathy groups were similar, patients with fragmented QRS had a markedly lower survival rate during the follow-up period, as mean of 15 months (p = 0.001).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123001774_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Our study showed that the presence of fragmented QRS may be an important ECG sign predicting an major adverse cardiac event and\/or cardiac death in patients with dilated cardiomyopathy. We believe that recognising fragmented QRS could be valuable in forecasting patient prognosis and identifying high-risk patients who require additional support.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951123001774","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T07:58:41Z","timestamp":1689321521000},"page":"380-386","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["The impact of fragmented QRS on clinical findings and outcomes in children with dilated cardiomyopathy with or without left ventricular non-compaction"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3298-5567","authenticated-orcid":false,"given":"\u00d6zlem","family":"Bayram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-0685","authenticated-orcid":false,"given":"Mehmet G.","family":"Ramo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9542-1937","authenticated-orcid":false,"given":"Selen","family":"Karag\u00f6zl\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeyhun","family":"Bakhtiyarzada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alperen","family":"Ayd\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anar","family":"Gurbanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3945-3384","authenticated-orcid":false,"given":"Beg\u00fcm","family":"Murt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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Ercan","family":"Tutar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"key":"S1047951123001774_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951120001262"},{"key":"S1047951123001774_ref14","first-page":"490","article-title":"Heart failure in children part 2: diagnosis, treatment and future directions","volume":"2","author":"Hsu","year":"2009","journal-title":"Circ: Heart Fail"},{"key":"S1047951123001774_ref13","volume-title":"Criteria Committee Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels","author":"Dolgin","year":"1994"},{"key":"S1047951123001774_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-011-0121-9"},{"key":"S1047951123001774_ref4","doi-asserted-by":"publisher","DOI":"10.4103\/2250-3528.191100"},{"key":"S1047951123001774_ref17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.940478"},{"key":"S1047951123001774_ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000682"},{"key":"S1047951123001774_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2015.06.381"},{"key":"S1047951123001774_ref18","article-title":"Predictive value of electrocardiographic markers in children with dilated cardiomyopathy","author":"Wang","year":"2022","journal-title":"Front Pediatr"},{"key":"S1047951123001774_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/heart.86.6.666"},{"key":"S1047951123001774_ref2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.973826"},{"key":"S1047951123001774_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.07.046"},{"key":"S1047951123001774_ref1","first-page":"988","volume-title":"In section 7, Diseases of the Endocardium, Myocardium, and Pericardium","author":"Shaddy","year":"2022"},{"key":"S1047951123001774_ref20","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10061232"},{"key":"S1047951123001774_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-020-02473-1"},{"key":"S1047951123001774_ref12","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv316"},{"key":"S1047951123001774_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61282-4"},{"key":"S1047951123001774_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.09.065"},{"key":"S1047951123001774_ref19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002511"},{"key":"S1047951123001774_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ipej.2019.12.005"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951123001774","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:10:34Z","timestamp":1708474234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951123001774\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,14]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S1047951123001774"],"URL":"https:\/\/doi.org\/10.1017\/s1047951123001774","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,14]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}