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During her hospitalisation, these episodes were associated with significant low cardiac output as evidenced by lactic acidosis and low mixed venous oxygen saturations. Her workup revealed an actin alpha cardiac muscle 1 (ACTC1) gene mutation and associated left ventricular non-compaction with decreased systolic function. She was started on oral heart failure medications as well as a calcium channel blocker but continued to have episodes which were found to promptly resolve with nitroglycerine. She was ultimately listed for cardiac transplant given her perceived risk of sudden death.<\/jats:p>","DOI":"10.1017\/s1047951123002640","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T08:57:47Z","timestamp":1690275467000},"page":"2440-2442","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Prinzmetal angina in a child with actin gene ACTC1 mutation"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0440-6249","authenticated-orcid":false,"given":"Donald","family":"Mattia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea","family":"Matney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-4714","authenticated-orcid":false,"given":"Steven","family":"Zangwill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethany","family":"Wisotzkey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Knoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"S1047951123002640_ref2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008068"},{"key":"S1047951123002640_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-009-9384-7"},{"key":"S1047951123002640_ref5","first-page":"5","article-title":"Mouse model of prinzmetal angina by disruption of the inward rectifier Kir6.1","volume":"8","author":"Miki","year":"2002","journal-title":"Nat Med 2022"},{"key":"S1047951123002640_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"S1047951123002640_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951117001652"},{"key":"S1047951123002640_ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0170"},{"key":"S1047951123002640_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2018.08.002"},{"key":"S1047951123002640_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-004-0811-5"},{"key":"S1047951123002640_ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.498006"},{"key":"S1047951123002640_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951112001278"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951123002640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T09:35:41Z","timestamp":1711445741000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951123002640\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,25]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S1047951123002640"],"URL":"https:\/\/doi.org\/10.1017\/s1047951123002640","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,25]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. 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