{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:02:36Z","timestamp":1778943756245,"version":"3.51.4"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951123003128_as1\"><jats:title>Objective:<\/jats:title><jats:p>Necrotising enterocolitis is linked with altered intestinal microbiota, and caesarean birth is associated with imbalance of newborn intestinal microbiome. We aimed to investigate the role of delivery mode (vaginal or caesarean) and gestational age in the development of necrotising enterocolitis among term-born neonates (\u2265 37 weeks) with CHD.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003128_as2\"><jats:title>Methods:<\/jats:title><jats:p>Case\u2013control study. We studied all newborns with CHD who underwent cardiac surgery during the neonatal (\u2264 28 days of age) period, between 2007 and 2017. Totally, 60 cases of necrotising enterocolitis were matched (by year of birth and type of congenital heart lesion) with 180 controls (1:3 ratio). Multivariable conditional logistic regression was used to assess the study question.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003128_as3\"><jats:title>Results:<\/jats:title><jats:p>The overall prevalence of necrotising enterocolitis was 6.3% in term-born newborns with CHD. Neonates with a left-ventricular outflow tract lesion or single ventricle lesion accounted for 55% (n = 33) of cases. 62% (n = 37) cases were in the modified Bell\u2019s stage 2 or more for necrotising enterocolitis classification. In multivariable modelling, gestational age at birth was not associated with the development of necrotising enterocolitis [adjusted odds ratio per week increase, 95% confidence interval: 1.20 (0.90\u20131.60)]. Birth by caesarean delivery (compared to vaginal) was strongly associated with development of necrotising enterocolitis [adjusted odds ratio (95% confidence interval): 2.64 (1.31\u20135.29)]. We failed to identify an association between preoperative enteral nutrition and necrotising enterocolitis.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003128_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>This study showed a high risk of necrotising enterocolitis in newborns with critical CHD born via caesarean. This information is important given the high prevalence of planned birth by caesarean in newborns with CHD.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951123003128","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T07:28:40Z","timestamp":1692775720000},"page":"576-580","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["High risk of necrotising enterocolitis in term-born neonates with CHD delivered by caesarean section: a case\u2013control study"],"prefix":"10.1017","volume":"34","author":[{"given":"Eloise","family":"Ihle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warwick","family":"Butt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1097-6256","authenticated-orcid":false,"given":"Siva P.","family":"Namachivayam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"S1047951123003128_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2012.04.011"},{"key":"S1047951123003128_ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000518498"},{"key":"S1047951123003128_ref26","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303249"},{"key":"S1047951123003128_ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005864"},{"key":"S1047951123003128_ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000244428"},{"key":"S1047951123003128_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951112001370"},{"key":"S1047951123003128_ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-1078-0"},{"key":"S1047951123003128_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-016-1552-y"},{"key":"S1047951123003128_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951120000785"},{"key":"S1047951123003128_ref11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2002"},{"key":"S1047951123003128_ref20","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516002944"},{"key":"S1047951123003128_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-021-02691-1"},{"key":"S1047951123003128_ref8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.5.1080"},{"key":"S1047951123003128_ref12","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.119064"},{"key":"S1047951123003128_ref1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0833hyp"},{"key":"S1047951123003128_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb00740.x"},{"key":"S1047951123003128_ref14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1668144"},{"key":"S1047951123003128_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(03)00187-8"},{"key":"S1047951123003128_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2018.08.001"},{"key":"S1047951123003128_ref21","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-318537"},{"key":"S1047951123003128_ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1560-1"},{"key":"S1047951123003128_ref22","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2019-0111"},{"key":"S1047951123003128_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(86)80228-7"},{"key":"S1047951123003128_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.04.074"},{"key":"S1047951123003128_ref24","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-1861"},{"key":"S1047951123003128_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90383-X"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951123003128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T10:58:03Z","timestamp":1709895483000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951123003128\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,23]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1047951123003128"],"URL":"https:\/\/doi.org\/10.1017\/s1047951123003128","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,23]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}