{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T04:09:23Z","timestamp":1747368563467,"version":"3.40.5"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951123003396_as1\"><jats:title>Background:<\/jats:title><jats:p>Low pre-albumin, body mass index, and thiamine levels have been associated with poor nutritional status and cognitive\/memory deficits in adult heart failure patients. However, the relationship of these nutritional\/dietary intake biomarkers to cognition has not been assessed in adolescents post-Fontan procedure and healthy controls.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003396_as2\"><jats:title>Methods:<\/jats:title><jats:p>This is a cross-sectional study. Adolescents (14\u201321 years of age) post-Fontan completion were recruited from paediatric cardiology clinics and controls from the community. The Montreal Cognitive Assessment was administered (normal \u2265 26), and blood draw (thiamine [normal 70\u2013110 nmol\/L] and pre-albumin levels [adolescent normal 23\u201345 mg\/dL]) and the Thiamine Food Frequency Questionnaire were completed by all participants.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003396_as3\"><jats:title>Results:<\/jats:title><jats:p>Seventy subjects, 40 post-Fontan (mean age 16 \u00b1 1.6, female 51%, Hispanic 44%, hypoplastic left heart syndrome 26%) and 30 controls (mean age 16.8 \u00b1 1.9, female 52%, Hispanic 66%), were participated. Post-Fontan group had lower median total cognitive scores (23 versus 29, p &lt; 0.001), pre-albumin levels (23 versus 27, p = 0.013), and body mass index (20 versus 24, p = 0.027) than controls. Post-Fontan group had higher thiamine levels than controls (127 versus 103, p = 0.033). Lower pre-albumin levels (&lt; 23) and underweight body mass index were associated with abnormal total cognitive scores (p = 0.030). Low pre-albumin level (p = .038) was an independent predictor of worse cognition.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003396_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Lower pre-albumin was an independent predictor for worse cognition in adolescents post-Fontan. Lower pre-albumin levels may reflect chronic liver changes or protein-losing enteropathy seen in Fontan physiology. These findings highlight the possibility for nutrition-induced cognitive changes.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951123003396","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T10:02:27Z","timestamp":1697623347000},"page":"803-808","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Low pre-albumin but not thiamine predicts cognitive deficits in adolescents post-Fontan and healthy controls"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6198-9957","authenticated-orcid":false,"given":"Nancy A.","family":"Pike","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Avedissian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy H.","family":"Halnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan B.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"S1047951123003396_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e32835dd005"},{"key":"S1047951123003396_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"S1047951123003396_ref14","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-305747"},{"key":"S1047951123003396_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0198-7"},{"key":"S1047951123003396_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13634"},{"key":"S1047951123003396_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/JCN.0b013e31822ce5f6"},{"key":"S1047951123003396_ref29","doi-asserted-by":"publisher","DOI":"10.1053\/jpdn.2002.124111"},{"key":"S1047951123003396_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2018.06.015"},{"key":"S1047951123003396_ref7","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0569-3"},{"key":"S1047951123003396_ref17","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015639"},{"key":"S1047951123003396_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(20)31266-3"},{"key":"S1047951123003396_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agad017"},{"key":"S1047951123003396_ref38","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.213579"},{"key":"S1047951123003396_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1977"},{"key":"S1047951123003396_ref27","first-page":"31","article-title":"Parental vigilance in caring for their children with hypoplastic left heart syndrome","volume":"41","author":"Meakins","year":"2015","journal-title":"Pediatr Nurs"},{"key":"S1047951123003396_ref36","doi-asserted-by":"publisher","DOI":"10.1177\/156482651003100109"},{"key":"S1047951123003396_ref18","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12751"},{"key":"S1047951123003396_ref28","first-page":"1","article-title":"Developing a sense of self-reliance: caregiving of infants with single-ventricle heart disease during the interstage period","volume":"24","author":"Imperial-Perez","year":"2021","journal-title":"Cardiol Young"},{"key":"S1047951123003396_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.02.048"},{"key":"S1047951123003396_ref24","unstructured":"24. 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Published by Cambridge University Press.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}