{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:37:17Z","timestamp":1788907037347,"version":"build-2803163510"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951123003761_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Direct oral anticoagulants have the potential to improve care in children requiring chronic anticoagulation. Edoxaban has favourable pharmacokinetics that could benefit younger patients but data on long-term safety and efficacy for specific paediatric indications are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951123003761_as2\">\n                    <jats:title>Study Aims:<\/jats:title>\n                    <jats:p>We present a single-centre experience using edoxaban in children who require chronic anticoagulation for large coronary artery aneurysms secondary to Kawasaki disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951123003761_as3\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Weight-based dosing of once-daily oral edoxaban was offered as alternative to standard anticoagulation for patients aged 1\u201318 years. Chart review was performed for a median follow-up period of 49 months on edoxaban. Steady-state pharmacokinetics and pharmacodynamics of edoxaban were also explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951123003761_as4\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixteen patients on chronic therapy with edoxaban were included. No major bleeding events were reported. Two patients experienced coronary artery thrombosis after 23 and 38 months on edoxaban, 7 and 11 years after diagnosed with Kawasaki disease, respectively. This predicts 70% event-free rate at 12 years from diagnosis. Area under the curve estimates over the dosing interval of 24 hours were similar to those reported in adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951123003761_as5\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Edoxaban use is feasible and well-tolerated for long-term use in paediatric population. We suggest appropriate exposure using weight-based once-daily dosing strategy that may be comparable to standard-of-care anticoagulation in prevention of coronary artery thrombosis. Larger studies are needed to evaluate long-term safety and efficacy of edoxaban in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951123003761","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T06:58:30Z","timestamp":1698994710000},"page":"870-875","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Real-world experience with edoxaban for anticoagulation in children at risk for coronary artery thrombosis"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7010-7722","authenticated-orcid":false,"given":"Eyal","family":"Sagiv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Newland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April","family":"Slee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron K.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Portman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"S1047951123003761_ref2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000484"},{"key":"S1047951123003761_ref31","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.736826"},{"key":"S1047951123003761_ref3","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.016440"},{"key":"S1047951123003761_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-015-0054-y"},{"key":"S1047951123003761_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.05.011"},{"key":"S1047951123003761_ref30","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15277"},{"key":"S1047951123003761_ref18","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"S1047951123003761_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-015-0342-7"},{"key":"S1047951123003761_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-022-00403-5"},{"key":"S1047951123003761_ref4","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2018.1.399"},{"key":"S1047951123003761_ref29","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001889"},{"key":"S1047951123003761_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2018.05.021"},{"key":"S1047951123003761_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14813"},{"key":"S1047951123003761_ref25","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2182"},{"key":"S1047951123003761_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30219-4"},{"key":"S1047951123003761_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951121002523"},{"key":"S1047951123003761_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30161-9"},{"key":"S1047951123003761_ref15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1055\/s-0038-1627480","article-title":"International council for standardization in haematology (ICSH) recommendations for laboratory measurement of direct oral anticoagulants","volume":"118","author":"Gosselin","year":"2018","journal-title":"Thromb Haemost"},{"key":"S1047951123003761_ref23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038998"},{"key":"S1047951123003761_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.08.002"},{"key":"S1047951123003761_ref17","unstructured":"17. 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Pediatric GFR Calculator. www.kidney.org\/professionals\/kdoqi\/gfr_calculatorPed (Accesseds 8\/7\/2023)."},{"key":"S1047951123003761_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.04.051"},{"key":"S1047951123003761_ref26","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2014-000206"},{"key":"S1047951123003761_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.12.073"},{"key":"S1047951123003761_ref22","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.3.307"},{"key":"S1047951123003761_ref14","doi-asserted-by":"publisher","DOI":"10.4155\/bio-2019-0180"},{"key":"S1047951123003761_ref11","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.021765"},{"key":"S1047951123003761_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.03.005"},{"key":"S1047951123003761_ref5","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2020.1823218"},{"key":"S1047951123003761_ref8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1055\/s-0039-3400491","article-title":"Use of direct oral anticoagulants in children and adolescents","volume":"40","author":"Albisetti","year":"2020","journal-title":"Hamostaseologie"},{"key":"S1047951123003761_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.09.031"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951123003761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T07:31:40Z","timestamp":1713166300000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951123003761\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,3]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1047951123003761"],"URL":"https:\/\/doi.org\/10.1017\/s1047951123003761","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,3]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. 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