{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:02:04Z","timestamp":1783987324706,"version":"3.55.0"},"reference-count":47,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951123003797_as1\"><jats:title>Background:<\/jats:title><jats:p>The main objective measure to assess the health of the Fontan circulation is the pressure measurement of the superior vena cava or pulmonary arteries. We reviewed the literature for benefits of measuring resting pressure in the Fontan circuit and explored whether dynamic measurement by volume loading or exercise has the potential to refine this diagnostic tool.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003797_as2\"><jats:title>Methods:<\/jats:title><jats:p>PubMed was searched for articles showing a relationship between resting post-operative central venous pressure or pulmonary artery pressure and Fontan failure. Relationships between post-operative central venous pressure or pulmonary artery pressure and volume loading changes, such as during exercise or volume loading during cardiac catheterization, were also queried.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003797_as3\"><jats:title>Results:<\/jats:title><jats:p>A total of 44 articles mentioned relationships between resting central venous pressure or pulmonary artery pressure and Fontan failure. Only 26 included an analysis between the variables and only seven of those articles found pressure to be predictive of Fontan failure. Ten articles examined the relationship between exercise or volume loading and outcomes and demonstrated a large individual variation of pressures under these dynamic conditions.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003797_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Based on current literature, there is not a lot of strong evidence to show that elevated resting central venous pressure or pulmonary artery pressure is predictive of Fontan failure. Some individuals experience dramatic increases in central venous pressure or pulmonary artery pressure under increased loading conditions with exercise or bolus fluid infusion, while others experience increases closer to that of a healthy control population. Further studies are needed to examine whether more dynamic and continuous monitoring of systemic venous pressures might better predict outcomes in patients with Fontan circulation.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951123003797","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T07:15:40Z","timestamp":1700464540000},"page":"969-980","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Are dynamic measurements of central venous pressure in Fontan circulation during exercise or volume loading superior to resting measurements?"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-0264","authenticated-orcid":false,"given":"Alyssia","family":"Venna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8358-9783","authenticated-orcid":false,"given":"Shriprasad","family":"Deshpande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2577-0074","authenticated-orcid":false,"given":"Tacy","family":"Downing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anitha","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"d\u2019Udekem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"S1047951123003797_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12345"},{"key":"S1047951123003797_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab826"},{"key":"S1047951123003797_ref38","first-page":"S89","article-title":"Pediatric cardiac intensive care society 2014 consensus statement: pharmacotherapies in cardiac critical care pulmonary hypertension","volume":"17","author":"Kim","year":"2016","journal-title":"Pediatr Crit Care Med J Soc Crit Care Med World Fed Pediatr Intensive Crit Care Soc"},{"key":"S1047951123003797_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(98)70406-4"},{"key":"S1047951123003797_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.09.044"},{"key":"S1047951123003797_ref29","doi-asserted-by":"publisher","DOI":"10.1177\/2047487317702042"},{"key":"S1047951123003797_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezw091"},{"key":"S1047951123003797_ref26","first-page":"ezaa310","article-title":"Evaluation of Fontan failure by classifying the severity of Fontan-associated liver disease: a single-centre cross-sectional study","volume":"28","author":"Schleiger","year":"2020","journal-title":"Eur J Cardio-Thorac Surg Off J Eur Assoc Cardio-Thorac Surg"},{"key":"S1047951123003797_ref10","first-page":"195","article-title":"Long-term serial aerobic exercise capacity and hemodynamic properties in clinically and hemodynamically good, \u201cexcellent","volume":"76","author":"Ohuchi","year":"2012","journal-title":"Fontan Survivors. 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