{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:58:46Z","timestamp":1747173526218,"version":"3.40.5"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951123003803_as1\"><jats:title>Background:<\/jats:title><jats:p>Acute asthma exacerbation is one of the most common reasons for paediatric emergency room visits and hospital admissions in the United States of America.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003803_as2\"><jats:title>Objective:<\/jats:title><jats:p>To assess the impact of CHD on outcomes of children hospitalised for acute asthma exacerbation.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003803_as3\"><jats:title>Methods:<\/jats:title><jats:p>Children primarily admitted for acute asthma exacerbation were sampled from 2006, 2009, 2012, and 2016 kid inpatient database of the Healthcare Cost and Utilization Project using ICD codes. The disease outcomes were compared between those with and without CHD using multivariate logistic regressions in Stata version 17.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003803_as4\"><jats:title>Results:<\/jats:title><jats:p>There were a total of 639,280 acute asthma exacerbation admissions, of which 5,907 (0.92%) had CHD. The mortality rate was 0.079% for patients without CHD and 0.72% for those with co-existing CHD. Children with CHD had higher odds of mortality (5.51, CI 3.40\u20138.93, p &lt; 0.001), acute respiratory failure (2.84, CI 2.53\u20133.20; p &lt; 0.001), need for invasive mechanical ventilation (4.58, CI 3.80\u20135.52; p &lt; 0.001), acute kidney injury (adjusted odds ratio 3.03, CI 3.03\u20137.44; p &lt; 0.001), and in-hospital cardiac arrest (adjusted odds ratio 4.52, CI 2.49\u20138.19; p &lt; 0.001) when compared with those without CHD. The adjusted mean length of hospital stays (CI 2.91\u20133.91; p &lt; 0.001) and hospital charges (95% CI $31060\u2013$47747) among children with acute asthma exacerbation and CHD were significantly higher than in those without CHD.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003803_as5\"><jats:title>Conclusion and Significance:<\/jats:title><jats:p>CHD is an independent predictor of mortality, more severe disease course, and higher hospital resource utilisation. Strategies that improve CHD care will likely improve the overall health outcomes of children with CHD hospitalised for acute asthma exacerbation.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951123003803","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T07:22:18Z","timestamp":1699600938000},"page":"884-890","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Impact of congenital heart disease on mortality and other associated outcomes in children hospitalised for acute asthma exacerbation"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3167-4414","authenticated-orcid":false,"given":"Ebenezer","family":"Adebiyi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Christine","family":"Munoz Pareja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Alba-Sandoval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvin","family":"Almodovar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"doi-asserted-by":"publisher","key":"S1047951123003803_ref3","DOI":"10.1542\/peds.2015-2354"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref13","DOI":"10.1186\/s12887-020-02344-x"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref7","DOI":"10.1155\/2018\/6460379"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref4","DOI":"10.1007\/s40273-018-0726-2"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref5","DOI":"10.3389\/fped.2019.00246"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref9","DOI":"10.1038\/s41598-021-81161-3"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref19","DOI":"10.1097\/HCO.0000000000000473"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref17","DOI":"10.1016\/j.prrv.2011.01.007"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref22","DOI":"10.1161\/JAHA.120.018286"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref1","DOI":"10.1378\/chest.91.6_Supplement.65S"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref6","DOI":"10.1164\/rccm.201606-1213PP"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref23","DOI":"10.1007\/s00246-017-1770-y"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref12","DOI":"10.1136\/heartjnl-2020-317706"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref2","DOI":"10.1289\/ehp.02110s4557"},{"unstructured":"15. CPI Inflation Calculator. [cited 2022; Available from: https:\/\/www.bls.gov\/data\/inflation_calculator.htm.","key":"S1047951123003803_ref15"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref16","DOI":"10.1542\/peds.105.2.332"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref20","DOI":"10.1007\/s00467-012-2292-8"},{"doi-asserted-by":"publisher","key":"S1047951123003803_ref11","DOI":"10.1016\/j.jacc.2018.08.1029"},{"key":"S1047951123003803_ref24","first-page":"5452683","article-title":"Characteristics, outcomes, and cost patterns of high-cost patients in the intensive care unit","volume":"2018","author":"Reardon","year":"2018","journal-title":"Crit Care Res Pract"},{"unstructured":"10. Overview of the Kids' Inpatient Database (KID). [cited 2020 12\/16\/2022]; Available from: https:\/\/hcup-us.ahrq.gov\/kidoverview.jsp. 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}