{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:30:30Z","timestamp":1778182230932,"version":"3.51.4"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951123003979_as1\"><jats:title>Background:<\/jats:title><jats:p>Neurocognitive impairment and quality of life are two important long-term challenges for patients with complex CHD. The impact of re-interventions during adolescence and young adulthood on neurocognition and quality of life is not well understood.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003979_as2\"><jats:title>Methods:<\/jats:title><jats:p>In this prospective longitudinal multi-institutional study, patients 13\u201330 years old with severe CHD referred for surgical or transcatheter pulmonary valve replacement were enrolled. Clinical characteristics were collected, and executive function and quality of life were assessed prior to the planned pulmonary re-intervention. These results were compared to normative data and were compared between treatment strategies.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003979_as3\"><jats:title>Results:<\/jats:title><jats:p>Among 68 patients enrolled from 2016 to 2020, a nearly equal proportion were referred for surgical and transcatheter pulmonary valve replacement (53% versus 47%). Tetralogy of Fallot was the most common diagnosis (59%) and pulmonary re-intervention indications included stenosis (25%), insufficiency (40%), and mixed disease (35%). There were no substantial differences between patients referred for surgical and transcatheter therapy. Executive functioning deficits were evident in 19\u201331% of patients and quality of life was universally lower compared to normative sample data. However, measures of executive function and quality of life did not differ between the surgical and transcatheter patients.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123003979_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>In this patient group, impairments in neurocognitive function and quality of life are common and can be significant. Given similar baseline characteristics, comparing changes in neurocognitive outcomes and quality of life <jats:italic>after<\/jats:italic> surgical versus transcatheter pulmonary valve replacement will offer unique insights into how treatment approaches impact these important long-term patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951123003979","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T07:21:33Z","timestamp":1701328893000},"page":"1018-1025","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Neurocognitive function and health-related quality of life in adolescents and young adults with CHD with pulmonary valve dysfunction"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5865-9591","authenticated-orcid":false,"given":"Jeffrey 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