{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:27:21Z","timestamp":1784042841886,"version":"3.55.0"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951123004249_as1\"><jats:title>Background:<\/jats:title><jats:p>CHD is a significant risk factor for the development of necrotising enterocolitis. Existing literature does not differentiate between term and preterm populations. Long-term outcomes of these patients are not well understood. The aim was to investigate the baseline characteristics and outcomes of term normal birth weight infants with CHD who developed necrotising enterocolitis.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123004249_as2\"><jats:title>Methods:<\/jats:title><jats:p>A retrospective review was performed of infants from a single tertiary centre with CHD who developed necrotising enterocolitis of Bell\u2019s Stage 1\u20133, over a ten-year period. Inclusion criteria was those born greater than 36 weeks\u2019 gestation and birth weight over 2500g. Exclusion criteria included congenital gastro-intestinal abnormalities. Sub-group analysis was performed using Fisher\u2019s exact test.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123004249_as3\"><jats:title>Results:<\/jats:title><jats:p>Twenty-five patients were identified, with a median gestational age of 38 weeks. Patients with univentricular physiology accounted for 32% (n = 8) and 52% of patients (n = 13) had a duct-dependent lesion. Atrioventricular septal defect was the most common cardiac diagnosis (n = 6, 24%). Patients with trisomy 21 accounted for 20% of cases. Mortality within 30 days of necrotising enterocolitis was 20%. Long-term mortality was 40%, which increased with increasing Bell\u2019s Stage. In total, 36% (n = 9) required surgical management of necrotising enterocolitis, the rate of which was significantly higher in trisomy 21 cases (p &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123004249_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Not previously described in term infants is the high rate of trisomy 21 and atrioventricular septal defect. This may reflect higher baseline incidence in our population. Infants with trisomy 21 were more likely to develop surgical necrotising enterocolitis. Mortality at long-term follow-up was high in patients with Bell\u2019s Stage 2\u20133.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951123004249","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T02:13:30Z","timestamp":1704161610000},"page":"1232-1238","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Outcomes and characteristics in term infants with necrotising enterocolitis and CHD"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-5462","authenticated-orcid":false,"given":"Sean T.","family":"Kelleher","sequence":"first","affiliation":[{"name":"Children\u2019s Health Ireland at Crumlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6246-3201","authenticated-orcid":false,"given":"John","family":"Coleman","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Ireland at Crumlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-9338","authenticated-orcid":false,"given":"Colin J.","family":"McMahon","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Ireland at Crumlin"},{"name":"School of Medicine, University College Dublin"},{"name":"School of Health Professions Education (SHE), Maastricht University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5023-9712","authenticated-orcid":false,"given":"Adam","family":"James","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Ireland at Crumlin"},{"name":"School of Medicine, Trinity College 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}