{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:22:25Z","timestamp":1782300145783,"version":"3.54.5"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"unspecified","delay-in-days":1,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951123004377_as1\"><jats:title>Introduction and aim:<\/jats:title><jats:p>In pediatric multisystem inflammatory syndrome and isolated viral myocarditis\/myopericarditis, autonomic nervous system function can be evaluated by a non-invasive method called heart rate variability. This study aims to evaluate heart rate variability in these two groups by comparing them with each other. This is the first study assessing these values in these two groups of patients.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123004377_as2\"><jats:title>Method:<\/jats:title><jats:p>Patients who are diagnosed with multisystem inflammatory syndrome in children and isolated viral myocarditis\/myopericarditis at a university hospital from September 2021 to February 2023 are screened by electrocardiography, echocardiography, and 24-hour Holter monitoring. A healthy control group, compatible in age and gender with the patient groups, was selected from healthy subjects that applied to the hospital for palpitation, murmur, and\/or chest pain. Heart rate variability parameters and related laboratory markers were analyzed and compared among the three groups.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123004377_as3\"><jats:title>Results:<\/jats:title><jats:p>There were 30 patients with multisystem inflammatory syndrome in children, 43 patients with isolated viral myocarditis\/myopericarditis, and 109 participants in the healthy control group. Statistically significant differences were found in most of the heart rate variability parameters: standard deviation of normal to normal intervals (SDNN), the mean of the 5- minute RR interval standard deviations (SDNN\u0130), the standard deviation of 5-minute R wave to R wave(RR) interval means (SDANN), the root mean square of successive RR interval differences (RMSSD), and the percentage of the beats with a consecutive RR interval difference of more than 50 ms (pNN50%), very low frequency, high frequency, low frequency, triangular index, and low frequency\/high-frequency ratio. Multisystem inflammatory syndrome in children patients had impaired and declined heart rate variability values compared to the other two groups. In patients with myocarditis\/myopericarditis, we couldn\u2019t find a significant difference in these parameters with the control group.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951123004377_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Heart rate variability can be used as an important non-invasive autonomic function parameter in determining prognosis and treatment plans, especially in patients diagnosed with multisystem inflammatory syndrome in children. This impairment of autonomic activity could be more prominent in patients with decreased left ventricular systolic functions.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951123004377","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T07:46:11Z","timestamp":1706859971000},"page":"421-427","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Assessing autonomic activity and prognostic risk factors comparing multisystem inflammatory syndrome and isolated viral myocarditis\/myopericarditis"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-1709","authenticated-orcid":false,"given":"Derya","family":"Duman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Karpuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"Ta\u015fdelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Necdet","family":"Kuyucu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"S1047951123004377_ref10","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.15585\/mmwr.mm6932e2","article-title":"COVID-19-associated multisystem inflammatory syndrome in children - United States, march-july 2020","volume":"69","author":"Godfred-Cato","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"S1047951123004377_ref29","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jpeds.2013.11.038","article-title":"Infection and other clinical correlates of abnormal heart rate characteristics in preterm infants","volume":"164","author":"Sullivan","year":"2014","journal-title":"J Pediatr"},{"key":"S1047951123004377_ref23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0167-5273(01)00537-X","article-title":"Heart rate variability in healthy children and adolescents is partially related to age and gender","volume":"81","author":"Silvetti","year":"2001","journal-title":"Int J Cardiol"},{"key":"S1047951123004377_ref16","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s10840-022-01138-8","article-title":"Heart rate variability and cardiac autonomic functions in post-COVID period","volume":"63","author":"Asarcikli","year":"2022","journal-title":"J Interv Card Electrophysiol"},{"key":"S1047951123004377_ref21","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/cpf.12096","article-title":"Normal values for heart rate variability parameters in children 6-8 years of age: the PANIC study","volume":"34","author":"Sepp\u00e4l\u00e4","year":"2014","journal-title":"Clin Physiol Funct Imaging"},{"key":"S1047951123004377_ref1","unstructured":"1 WHOD-Gsratmbo-noFAa. http:\/\/www.who.int\/dg\/speeches\/detail\/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020. 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