{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T06:30:44Z","timestamp":1766557844289,"version":"3.44.0"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951124000076_as1\"><jats:title>Introduction:<\/jats:title><jats:p>Proteomics may help discover novel biomarkers and underlying mechanisms for cardiovascular disease. This could be useful for childhood cancer survivors as they show an increased risk of cardiovascular disease. The aim of this study was to investigate circulating cardiovascular proteins in young adult survivors of childhood cancer and their relationship to previously reported subclinical cardiovascular disease.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124000076_as2\"><jats:title>Methods:<\/jats:title><jats:p>Ninety-two cardiovascular proteins were measured in 57 childhood cancer survivors and in 52 controls. For proteins that were significantly different between childhood cancer survivors and controls, we performed correlations between protein levels and measures of peripheral arterial stiffness (carotid distensibility and stiffness index, and augmentation index) and endothelial dysfunction (reactive hyperemia index).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124000076_as3\"><jats:title>Results:<\/jats:title><jats:p>Leptin was significantly higher in childhood cancer survivors compared to controls (normalized protein expression units: childhood cancer survivors 6.4 (1.5) versus 5.1 (1.7), p &lt; 0.0000001) after taking multiple tests into account. Kidney injury molecule-1, MER proto-oncogene tyrosine kinase, selectin P ligand, decorin, alpha-1-microglobulin\/bikunin precursor protein, and pentraxin 3 showed a trend towards group differences (p &lt; 0.05). Among childhood cancer survivors, leptin was associated with anthracycline treatment after adjustment for age, sex, and body mass index (p &lt; 0.0001). Higher leptin correlated with lower carotid distensibility after adjustment for age, sex, body mass index, and treatments with radiotherapy and anthracyclines (p = 0.005).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124000076_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>This proteomics approach identified that leptin is higher in young asymptomatic adult survivors of childhood cancer than in healthy controls and is associated with adverse vascular changes. This could indicate a role for leptin in driving the cardiovascular disease burden in this population.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951124000076","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T04:53:56Z","timestamp":1706849636000},"page":"1325-1333","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Circulating leptin is associated with adverse vascular changes in young adult survivors of childhood cancer"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1566-5780","authenticated-orcid":false,"given":"Olof","family":"Broberg","sequence":"first","affiliation":[{"name":"Sk\u00e5ne University Hospital"},{"name":"Lund University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Feldreich","sequence":"additional","affiliation":[{"name":"School of Health and Welfare Dalarna University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7477-7283","authenticated-orcid":false,"given":"Constance G.","family":"Weismann","sequence":"additional","affiliation":[{"name":"Sk\u00e5ne University Hospital"},{"name":"Lund University"},{"name":"Ludwig-Maximilian University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"\u00d8ra","sequence":"additional","affiliation":[{"name":"Lund University"},{"name":"Sk\u00e5ne University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Wiebe","sequence":"additional","affiliation":[{"name":"Lund University"},{"name":"Sk\u00e5ne University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"\u00c4rnl\u00f6v","sequence":"additional","affiliation":[{"name":"School of Health and Welfare Dalarna University"},{"name":"Care Sciences and Society (NVS), Karolinska 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2024. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}