{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:32:16Z","timestamp":1767339136307,"version":"3.40.5"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S104795112400012X_as1\"><jats:title>Objectives:<\/jats:title><jats:p>Atrioventricular valve regurgitation in patients with univentricular heart is a well-known risk factor for adverse outcomes and atrioventricular valve repair remains a particular surgical challenge.<\/jats:p><\/jats:sec><jats:sec id=\"S104795112400012X_as2\"><jats:title>Methods:<\/jats:title><jats:p>We reviewed all surgical atrioventricular valve procedures in patients with univentricular heart and two separate atrioventricular valves who underwent surgical palliation. Endpoints of the study were reoperation-free survival and cumulative incidence of reoperation.<\/jats:p><\/jats:sec><jats:sec id=\"S104795112400012X_as3\"><jats:title>Results:<\/jats:title><jats:p>Between 1994 and 2021, 202 patients with univentricular heart and two separate atrioventricular valve morphology underwent surgical palliation, with 15.8% (32\/202) requiring atrioventricular valve surgery. Primary diagnoses were double inlet left ventricle (n = 14, 43.8%), double outlet right ventricle (n = 7, 21.9%), and congenitally corrected transposition of the great arteries (n = 7, 21.9%). Median weight at valve surgery was 10.6 kg (interquartile range, 7.9\u201318.9). Isolated left or right atrioventricular valve surgery was required in nine (28.1%) and 22 patients (68.8%), respectively. Concomitant left and right atrioventricular valve surgery was performed in one patient (3.1%). Closure of the left valve was conducted in four patients (12.5%) and closure of the right valve in three (9.4%). Operative and late mortality were 3.1% and 9.7%, respectively. Reoperation-free survival and cumulative incidence of reoperation at 10 years after surgery were 62.3% (standard error of the mean: 6.9) and 30.9% (standard error of the mean: 9.6), respectively.<\/jats:p><\/jats:sec><jats:sec id=\"S104795112400012X_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>In patients with univentricular heart and two separate atrioventricular valves, surgical intervention on these valves is required in a minority of patients and is associated with low mortality but high incidence of reoperation.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s104795112400012x","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T12:57:03Z","timestamp":1712149023000},"page":"1554-1562","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Atrioventricular valve surgery in patients with univentricular heart and two separate atrioventricular valves"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1164-0746","authenticated-orcid":false,"given":"Benedikt","family":"Mayr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Osawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4034-3967","authenticated-orcid":false,"given":"Helena","family":"Staehler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thibault","family":"Schaeffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"R\u00f6hlig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Cleuziou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"Hager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ewert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"H\u00f6rer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5699-6394","authenticated-orcid":false,"given":"Masamichi","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"doi-asserted-by":"publisher","key":"S104795112400012X_ref14","DOI":"10.1007\/s00246-021-02639-5"},{"key":"S104795112400012X_ref6","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/ejcts\/ezz324","article-title":"Atrioventricular valve closure in Fontan palliation","volume":"57","author":"King","year":"2020","journal-title":"Eur J Cardiothorac Surg"},{"doi-asserted-by":"publisher","key":"S104795112400012X_ref7","DOI":"10.1016\/j.jtcvs.2010.05.024"},{"doi-asserted-by":"publisher","key":"S104795112400012X_ref9","DOI":"10.1177\/2150135112461924"},{"doi-asserted-by":"publisher","key":"S104795112400012X_ref1","DOI":"10.1161\/JAHA.119.015737"},{"doi-asserted-by":"publisher","key":"S104795112400012X_ref4","DOI":"10.1016\/j.jtcvs.2017.06.042"},{"key":"S104795112400012X_ref2","first-page":"88","volume-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu","volume":"15","author":"Sano","year":"2012"},{"key":"S104795112400012X_ref5","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jacc.2018.12.025","article-title":"Atrioventricular valve failure in Fontan palliation","volume":"73","author":"King","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"S104795112400012X_ref11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/2150135119884916","article-title":"Atrioventricular valve repair in single ventricle physiology: timing matters","volume":"11","author":"Miana","year":"2020","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"S104795112400012X_ref15","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0003-4975(01)02699-6","article-title":"Atrioventricular valve replacement in patients with a single ventricle","volume":"72","author":"Mahle","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"S104795112400012X_ref3","first-page":"61","volume-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu","volume":"15","author":"Tsang","year":"2012"},{"key":"S104795112400012X_ref13","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.athoracsur.2006.02.007","article-title":"Analysis of surgical outcome in complex double-outlet right ventricle with heterotaxy syndrome or complete atrioventricular canal defect","volume":"82","author":"Takeuchi","year":"2006","journal-title":"Ann Thorac Surg"},{"doi-asserted-by":"publisher","key":"S104795112400012X_ref17","DOI":"10.1016\/S0003-4975(10)60916-2"},{"key":"S104795112400012X_ref10","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jtcvs.2010.11.060","article-title":"Atrioventricular valve repair in patients with functional single-ventricle physiology: impact of ventricular and valve function and morphology on survival and reintervention","volume":"142","author":"Honjo","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"doi-asserted-by":"publisher","key":"S104795112400012X_ref12","DOI":"10.1093\/ejcts\/ezab220"},{"key":"S104795112400012X_ref8","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.jtcvs.2017.08.122","article-title":"Atrioventricular valve regurgitation in patients undergoing total cavopulmonary connection: impact of valve morphology and underlying mechanisms on survival and reintervention","volume":"155","author":"Ono","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"S104795112400012X_ref16","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/icvts\/ivy155","article-title":"Mid-term result of atrioventricular valve replacement in patients with a single ventricle","volume":"27","author":"Sughimoto","year":"2018","journal-title":"Interact CardioVasc Thorac Surg"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S104795112400012X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T08:04:26Z","timestamp":1729843466000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S104795112400012X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,3]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S104795112400012X"],"URL":"https:\/\/doi.org\/10.1017\/s104795112400012x","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2024,4,3]]},"assertion":[{"value":"\u00a9 The Author(s), 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}