{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:22:14Z","timestamp":1793215334742,"version":"4.5.0"},"reference-count":47,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951124000465_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Multisystem inflammatory syndrome in children is an inflammatory syndrome related to severe acute respiratory syndrome coronavirus 2 with a high risk of cardiovascular complications (vasoplegia, cardiac shock). We investigated the cardiac outcomes in multisystem inflammatory syndrome in children, focusing on the identification of predictors for late cardiac function impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951124000465_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Clinical characteristics, conventional echocardiography (left ventricle ejection fraction, fractional shortening), 4-chamber left ventricular global longitudinal strain, and cardiac MRI of multisystem inflammatory syndrome in children patients (n = 48) were collected during admission, 6 weeks, 6 months, &gt;12\u2013\u226418 months, and &gt;18\u2013\u226424 months post-onset. Paired over-time patterns were assessed and multivariable regression analyses were performed to identify predictors for late global longitudinal strain impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951124000465_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 81.3% of patients had acute cardiac dysfunction (left ventricle ejection fraction &lt;50% and\/or fractional shortening &lt;28%). The left ventricle ejection fraction and fractional shortening reached a plateau level \u22646 weeks, while the global longitudinal strain continued to decrease in the first 6 months post-onset (median \u201317.3%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001 [versus acute]). At 6 months, 35.7% of the patients still had an abnormal global longitudinal strain, which persisted in 5\/9 patients that underwent echocardiography &gt;12\u2013\u226418 months post-onset and in 3\/3 patients &gt;18\u2013\u226424 months post-onset. In a multivariable analysis, soluble troponin T (&gt;62.0 ng\/L [median]) was associated with reduced global longitudinal strain at 6 months. Our cardiac MRI findings indicated acute myocardial involvement (increased T1\/T2 value) in 77.8% (7\/9), which recovered quickly without signs of fibrosis on convalescent cardiac MRIs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951124000465_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Late global longitudinal strain impairment is seen in some multisystem inflammatory syndrome in children patients up to one-year post-onset. Careful cardiac follow-up in patients with elevated troponin in the acute phase and patients with persistent abnormal global longitudinal strain is warranted until resolution of the global longitudinal strain since the long-term implications of such abnormalities are still unclear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951124000465","type":"journal-article","created":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T23:51:01Z","timestamp":1712533861000},"page":"1683-1692","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":9,"title":["Long-term global longitudinal strain abnormalities in paediatric patients after multisystem inflammatory syndrome in children correlate with cardiac troponin T: a single-centre cohort study"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3495-4705","authenticated-orcid":false,"given":"Stejara A.","family":"Netea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giske","family":"Biesbroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Groenink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.N. (Nils)","family":"Planken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbert J.","family":"de Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Kawasaki Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico A.","family":"Blom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taco W.","family":"Kuijpers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene M.","family":"Kuipers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"S1047951124000465_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"S1047951124000465_ref15","first-page":"1","article-title":"Segmental and global longitudinal strain differences between Kawasaki disease and multi-system inflammatory syndrome in children","volume":"33","author":"Piccinelli","year":"2022","journal-title":"Cardiol Young"},{"key":"S1047951124000465_ref39","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27870"},{"key":"S1047951124000465_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023251"},{"key":"S1047951124000465_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2020.07.019"},{"key":"S1047951124000465_ref46","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-022-02787-6"},{"key":"S1047951124000465_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.03.041"},{"key":"S1047951124000465_ref43","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038529"},{"key":"S1047951124000465_ref42","doi-asserted-by":"publisher","DOI":"10.1172\/JCI141113"},{"key":"S1047951124000465_ref17","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153360"},{"key":"S1047951124000465_ref33","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.626182"},{"key":"S1047951124000465_ref8","first-page":"1","article-title":"Longitudinal assessment of cardiac function following multisystem inflammatory syndrome in children associated with COVID-19","volume":"44","author":"Das","year":"2022","journal-title":"Pediatr Cardiol"},{"key":"S1047951124000465_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-022-03021-9"},{"key":"S1047951124000465_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002850"},{"key":"S1047951124000465_ref38","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-021-00786-5"},{"key":"S1047951124000465_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10369"},{"key":"S1047951124000465_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.056"},{"key":"S1047951124000465_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeaa212"},{"key":"S1047951124000465_ref27","unstructured":"27. 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}