{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:59:00Z","timestamp":1747173540069,"version":"3.40.5"},"reference-count":51,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951124000647_as1\"><jats:title>Background:<\/jats:title><jats:p>Invasive haemodynamics are often performed for initiating and guiding pulmonary artery hypertension therapy. Little is known about the predictive value of invasive haemodynamic indices for long-term outcomes in children with pulmonary artery hypertension. We aimed to evaluate invasive haemodynamic data to help predict outcomes in paediatric pulmonary artery hypertension.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124000647_as2\"><jats:title>Methods:<\/jats:title><jats:p>Patients with pulmonary artery hypertension who underwent cardiac catheterisation (2006\u20132019) at a single centre were included. Invasive haemodynamic data from the first cardiac catheterisation and clinical outcomes were reviewed. The combined adverse outcome was defined as pericardial effusion (due to right ventricle failure), creation of a shunt for pulmonary artery hypertension (atrial septal defect or reverse Pott\u2019s shunt), lung transplant, or death.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124000647_as3\"><jats:title>Results:<\/jats:title><jats:p>Among 46 patients with a median [interquartile range (IQR)] age of 13.2 [4.1\u201344.7] months, 76% had CHD. Median mean pulmonary artery pressure was 37 [28\u201352] mmHg and indexed pulmonary vascular resistance was 6.2 [3.6\u201310] Woods units \u00d7 m<jats:sup>2<\/jats:sup>. Median pulmonary artery pulsatility index was 4.0 [3.0\u20134.7] and right ventricular stroke work index was 915 [715\u20131734] mmHg mL\/m<jats:sup>2<\/jats:sup>. After a median follow-up of 2.4 years, nine patients had a combined adverse outcome (two had a pericardial effusion, one underwent atrial level shunt, one underwent reverse Pott\u2019s shunt, and six died). Patients with an adverse outcome had higher systolic and mean pulmonary artery pressures, higher diastolic and transpulmonary pressure gradients, higher indexed pulmonary vascular resistance, higher pulmonary artery elastance, and higher right ventricular stroke work index (p &lt; 0.05 each).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124000647_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Invasive haemodynamics (especially mean pulmonary artery pressure and diastolic pressure gradient) obtained at first cardiac catheterisation in children with pulmonary artery hypertension predicts outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951124000647","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T08:06:11Z","timestamp":1712217971000},"page":"1563-1570","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Invasive haemodynamics predict outcomes in paediatric pulmonary artery hypertension"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8542-8679","authenticated-orcid":false,"given":"Rupesh Kumar","family":"Natarajan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Rodgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanti","family":"Narasimhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Ambrose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Rothman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Shyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varun","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"S1047951124000647_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000222107.15548.f5"},{"key":"S1047951124000647_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-019-00289-2"},{"key":"S1047951124000647_ref38","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.12152"},{"key":"S1047951124000647_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.02.023"},{"key":"S1047951124000647_ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2016.06.022"},{"key":"S1047951124000647_ref29","first-page":"329","article-title":"Invasive hemodynamics of pulmonary disease and the right ventricle","volume":"6","author":"Silber","year":"2017","journal-title":"Interv Cardiol Clin"},{"key":"S1047951124000647_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/11.suppl_I.1"},{"key":"S1047951124000647_ref27","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.17-576"},{"key":"S1047951124000647_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.06.064"},{"key":"S1047951124000647_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.08.024"},{"key":"S1047951124000647_ref40","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"S1047951124000647_ref1","doi-asserted-by":"publisher","DOI":"10.1086\/690007"},{"key":"S1047951124000647_ref33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00336.2006"},{"key":"S1047951124000647_ref4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202011-4183OC"},{"key":"S1047951124000647_ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.026591"},{"key":"S1047951124000647_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.054"},{"key":"S1047951124000647_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.09.032"},{"key":"S1047951124000647_ref9","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.182378"},{"key":"S1047951124000647_ref37","first-page":"e80235","volume-title":"PLoS One","volume":"8","author":"Wagner","year":"2013"},{"key":"S1047951124000647_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.12.080"},{"key":"S1047951124000647_ref47","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.23309"},{"key":"S1047951124000647_ref16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1356461"},{"key":"S1047951124000647_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr282"},{"key":"S1047951124000647_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.04.062"},{"key":"S1047951124000647_ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503184"},{"key":"S1047951124000647_ref13","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318163a2e7"},{"key":"S1047951124000647_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.012"},{"key":"S1047951124000647_ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1999.tb05200.x"},{"key":"S1047951124000647_ref30","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12860"},{"key":"S1047951124000647_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.06.014"},{"key":"S1047951124000647_ref21","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu365"},{"key":"S1047951124000647_ref31","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03337-2020"},{"key":"S1047951124000647_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.01.038"},{"key":"S1047951124000647_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.07.017"},{"key":"S1047951124000647_ref28","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-305298"},{"key":"S1047951124000647_ref43","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl477"},{"key":"S1047951124000647_ref44","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"S1047951124000647_ref2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.969584"},{"key":"S1047951124000647_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61621-8"},{"key":"S1047951124000647_ref25","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201509-599FR"},{"key":"S1047951124000647_ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213917"},{"key":"S1047951124000647_ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1413687"},{"key":"S1047951124000647_ref35","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.9.1197"},{"key":"S1047951124000647_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00155-1"},{"key":"S1047951124000647_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.01.1252"},{"key":"S1047951124000647_ref11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0187"},{"key":"S1047951124000647_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/4.1.23"},{"key":"S1047951124000647_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.03.009"},{"key":"S1047951124000647_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.06.009"},{"key":"S1047951124000647_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2015.10.019"},{"key":"S1047951124000647_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.04.280"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951124000647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T08:04:52Z","timestamp":1729843492000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951124000647\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,4]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S1047951124000647"],"URL":"https:\/\/doi.org\/10.1017\/s1047951124000647","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2024,4,4]]},"assertion":[{"value":"\u00a9 The Author(s), 2024. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}