{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:47:02Z","timestamp":1786999622104,"version":"build-2736575974"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951124000726_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Head-up tilt test (HUTT) is an important tool in the diagnosis of pediatric vasovagal syncope. This research will explore the relationship between syncopal symptoms and HUTT modes in pediatric vasovagal syncope.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951124000726_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective analysis was performed on the clinical data of 2513 children aged 3\u201318 years, who were diagnosed with vasovagal syncope, from Jan. 2001 to Dec. 2021 due to unexplained syncope or pre-syncope. The average age was 11.76 \u00b1 2.83 years, including 1124 males and 1389 females. The patients were divided into the basic head-up tilt test (BHUT) group (596 patients) and the sublingual nitroglycerine head-up tilt test (SNHUT) group (1917 patients) according to the mode of positive HUTT at the time of confirmed pediatric vasovagal syncope.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951124000726_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      (1) Baseline characteristics: Age, height, weight, heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and composition ratio of syncope at baseline status were higher in the BHUT group than in the SNHUT group (all\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). (2) Univariate analysis: Age, height, weight, HR, SBP, DBP, and syncope were potential risk factors for BHUT positive (all\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). (3) Multivariate analysis: syncope was an independent risk factor for BHUT positive, with a probability increase of 121% compared to pre-syncope (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951124000726_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The probability of BHUT positivity was significantly higher than SNHUT in pediatric vasovagal syncope with previous syncopal episodes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951124000726","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T04:44:26Z","timestamp":1712292266000},"page":"1583-1588","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Relationship between syncopal symptoms and head-up tilt test modes"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5095-1435","authenticated-orcid":false,"given":"Shuo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4428-4311","authenticated-orcid":false,"given":"Yali","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1627-8918","authenticated-orcid":false,"given":"Yuwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5651-6047","authenticated-orcid":false,"given":"Yi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heli","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2094-1828","authenticated-orcid":false,"given":"Donglei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6398-0697","authenticated-orcid":false,"given":"Hong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meihua","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3840-855X","authenticated-orcid":false,"given":"Runmei","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7120-0654","authenticated-orcid":false,"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"S1047951124000726_ref37","first-page":"202","article-title":"Does body height affect the severity of chronic venous disease in lower extremities?","volume":"61","author":"Sp\u00e1\u010dil","year":"2015","journal-title":"Vnitr Lek"},{"key":"S1047951124000726_ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01329"},{"key":"S1047951124000726_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.03.029"},{"key":"S1047951124000726_ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.663016"},{"key":"S1047951124000726_ref21","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy037"},{"key":"S1047951124000726_ref28","first-page":"43","article-title":"Clinical significance of abdominal pain and other gastrointestinal manifestations in children with autonomic nervous-mediated syncope","volume":"28","author":"Yan","year":"2013","journal-title":"Chin J Pract Pediatr"},{"key":"S1047951124000726_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2020.06.006"},{"key":"S1047951124000726_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2012.11.006"},{"key":"S1047951124000726_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(02)76640-2"},{"key":"S1047951124000726_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-021-00495-0"},{"key":"S1047951124000726_ref24","first-page":"36","article-title":"The effect of telephone appointment-reminder calls on outpatient absenteeism in a pulmonary function laboratory","volume":"51","author":"Haynes","year":"2006","journal-title":"Respir Care."},{"key":"S1047951124000726_ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1030618"},{"key":"S1047951124000726_ref35","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.108098"},{"key":"S1047951124000726_ref34","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14342"},{"key":"S1047951124000726_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2012.11.013"},{"key":"S1047951124000726_ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00098"},{"key":"S1047951124000726_ref36","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe9459"},{"key":"S1047951124000726_ref38","doi-asserted-by":"publisher","DOI":"10.7570\/jomes20041"},{"key":"S1047951124000726_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2018.09.019"},{"key":"S1047951124000726_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-019-00383-8"},{"key":"S1047951124000726_ref20","first-page":"e60","article-title":"2017 ACC\/AHA\/HRS guideline for the evaluation and management of patients with syncope: a report of the American college of cardiology\/American heart association task force on clinical practice guidelines and the heart rhythm society","volume":"2017","author":"Shen","year":"2017","journal-title":"Circulation"},{"key":"S1047951124000726_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2023.01.001"},{"key":"S1047951124000726_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00500-8"},{"key":"S1047951124000726_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.04.086"},{"key":"S1047951124000726_ref25","first-page":"796","article-title":"Diagnostic difference of head-up tilt table test in the patients of unexplained dizziness and syncope","volume":"25","author":"Wang","year":"2005","journal-title":"Chin J Care Med"},{"key":"S1047951124000726_ref15","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.219157"},{"key":"S1047951124000726_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04956-8"},{"key":"S1047951124000726_ref32","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13792"},{"key":"S1047951124000726_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2011.08.007"},{"key":"S1047951124000726_ref7","first-page":"64","article-title":"Diagnosis and treatment of malignant vasovagal syncope in children","volume":"60","author":"Xu","year":"2022","journal-title":"Chin J Pediatr."},{"key":"S1047951124000726_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2019.12.026"},{"key":"S1047951124000726_ref31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb03619.x"},{"key":"S1047951124000726_ref3","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.881795"},{"key":"S1047951124000726_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2014.09.019"},{"key":"S1047951124000726_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.11.022"},{"key":"S1047951124000726_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.11.039"},{"key":"S1047951124000726_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab041"},{"key":"S1047951124000726_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-1904-x"},{"key":"S1047951124000726_ref17","doi-asserted-by":"publisher","DOI":"10.1136\/adc.82.2.154"},{"key":"S1047951124000726_ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.901919"},{"key":"S1047951124000726_ref30","first-page":"e2119","article-title":"Association between baseline blood pressures, heart rates, and vasovagal syncope in children and adolescents","volume":"10","author":"Adlakha","year":"2018","journal-title":"Cureus"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951124000726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T04:04:59Z","timestamp":1729829099000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951124000726\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,5]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S1047951124000726"],"URL":"https:\/\/doi.org\/10.1017\/s1047951124000726","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,5]]},"assertion":[{"value":"\u00a9 The Author(s), 2024. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}