{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:34:17Z","timestamp":1763202857750,"version":"3.40.5"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951124000799_as1\"><jats:title>Background:<\/jats:title><jats:p>Aortopathy in Turner syndrome is associated with aortic dilation, and the risk of dissection is increased when the aortic size index is \u2265 2\u20132.5 cm\/m<jats:sup>2<\/jats:sup>. We evaluated the aortic biophysical properties in paediatric Turner syndrome using cardiac MRI to determine their relationship to aortic size index.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124000799_as2\"><jats:title>Methods:<\/jats:title><jats:p>Turner syndrome patients underwent cardiac MRI to evaluate ventricular function, aortic dimensions, and biophysical properties (aortic stiffness index, compliance, distensibility, pulse wave velocity, and aortic and left ventricular elastance). Spearman correlation examined correlations between these properties and aortic size index. Data was compared to 10 controls.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124000799_as3\"><jats:title>Results:<\/jats:title><jats:p>Of 25 Turner syndrome patients, median age 14.7 years (interquartile range: 11.0\u201316.8), height z score \u22122.7 (interquartile range: \u22122.92 \u2013 \u22121.54), 24% had a bicuspid aortic valve. Turner syndrome had increased diastolic blood pressure (p &lt; 0.001) and decreased left ventricular end-diastolic (p &lt; 0.001) and end-systolic (p = 0.002) volumes compared to controls. Median aortic size index was 1.81 cm\/m<jats:sup>2<\/jats:sup> (interquartile range: 1.45\u20132.1) and 7 had an aortic size index &gt; 2 cm\/m<jats:sup>2<\/jats:sup>. Aortic and left ventricular elastance were greater in Turner syndrome compared to controls (both p &lt; 0.001). Increased aortic size index correlated with increased aortic elastance (r = 0.5, p = 0.01) and left ventricular elastance (r = 0.59, p = 0.002) but not aortic compliance. Higher ascending aortic areas were associated with increased aortic compliance (r = 0.44, p = 0.03) and left ventricular elastance (r = 0.49, p = 0.01).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124000799_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Paediatric Turner syndrome with similar aortic size index to controls showed MRI evidence of abnormal aortic biophysical properties. These findings point to an underlying aortopathy and provide additional parameters that may aid in determining risk factors for aortic dissection.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951124000799","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T09:56:57Z","timestamp":1712915817000},"page":"1764-1770","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Cardiac MRI evaluation of aortic biophysical properties in paediatric Turner syndrome"],"prefix":"10.1017","volume":"34","author":[{"given":"Somjate","family":"Suntratonpipat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiera","family":"Pajunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Rosolowsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina A.","family":"Escudero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Girgis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard B.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph 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aortic stiffening in Turner patients may be present before dilation can be detected: a segmental functional MRI study","volume":"19","author":"Devos","year":"2017","journal-title":"J Cardiovasc Magn Reson"},{"key":"S1047951124000799_ref3","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0430"},{"key":"S1047951124000799_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/BF02427041"},{"key":"S1047951124000799_ref7","first-page":"1","article-title":"Aortic elasticity deterioration proves intrinsic abnormality of the ascending aorta in pediatric Turner syndrome unrelated to the aortic valve morphology","volume":"331","author":"Pees","year":"2018","journal-title":"Heart Vessels"}],"container-title":["Cardiology in the 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