{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:44:54Z","timestamp":1784022294479,"version":"3.55.0"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"unspecified","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951124025599_as1\"><jats:title>Background:<\/jats:title><jats:p>Ebstein\u2019s anomaly represents 40% of congenital tricuspid valve abnormalities. Studies about paediatric Ebstein\u2019s anomaly patients are limited.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124025599_as2\"><jats:title>Aim:<\/jats:title><jats:p>To evaluate clinical characteristics, treatment (medical\/arrhythmia ablation\/surgical) results, and outcome of Ebstein\u2019s anomaly patients, and to determine factors affecting arrhythmia presence and mortality.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124025599_as3\"><jats:title>Methods:<\/jats:title><jats:p>Clinical data, echocardiography, treatment results, and outcomes of patients followed in our centre between 2000 and 2017 were retrospectively evaluated.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124025599_as4\"><jats:title>Results:<\/jats:title><jats:p>A total of 79 patients (61 children, median diagnosis age: 1.5 years [1 day\u201324 years]) were included. Eight patients (10.1%) were deceased during the study period. Common associated anomalies were atrial septal defect\/patent foramen ovale (56.9%), mitral regurgitation (25.3%), pulmonary stenosis\/atresia (17.7%), and ventricular septal defect (16.5%). Genetic diseases\/congenital anomalies were present in 5\/3.8%. Tricuspid regurgitation was present in 75.9%, and severe in 50%. Arrhythmias were detected in 30.4%, and accessory pathway-mediated re-entrant tachycardia was the most common (67%). Wolff-Parkinson-White syndrome was present in 12.7%. Twenty-one ablation procedures (radiofrequency ablation [85.7%]\/cryoablation [14.3%]) were performed in 16 patients (median age: 13.3 years [4.9\u201317]). Acute success\/recurrence rates: 87.5\/25%. Surgery was performed in 31.6% (median age: 6.5 years [4 days\u201329 years]), 7.6% were operated during the first month, and 12.6% during the first year. Second surgery was required in 28%. Perioperative mortality rate was 12%, and median mortality age was 25 days (1 day\u201317 years). Median follow-up period was 5.3 years (1 day\u201332 years). Older diagnosis age (<jats:italic>p<\/jats:italic> = 0.005) and mild-moderate mitral regurgitation (<jats:italic>p<\/jats:italic> = 0.036) were associated with arrhythmias. Younger age at diagnosis (<jats:italic>p<\/jats:italic> = 0.012), younger age at first surgery (<jats:italic>p<\/jats:italic> = 0.004), surgery before age three years (<jats:italic>p<\/jats:italic> = 0.037), and presence of pulmonary atresia (<jats:italic>p<\/jats:italic> = 0.000014) were associated with mortality. Gender, diagnosis age, congenital anomalies\/genetic disorders, tricuspid regurgitation, arrhythmias, and surgery history did not have an independent effect on survival.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124025599_as5\"><jats:title>Conclusions:<\/jats:title><jats:p>In children and young adults presenting with Ebstein\u2019s anomaly, younger age at presentation and at surgery, surgery before age three years, pulmonary atresia were associated with death. Ablation procedures can be successfully performed but recurrence rate is still high.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951124025599","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T08:33:42Z","timestamp":1736498022000},"page":"38-45","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Ebstein\u2019s anomaly in children and young adults: clinical features, arrhythmia, surgical management, and factors affecting arrhythmia and mortality"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6612-1524","authenticated-orcid":false,"given":"Ayd\u0131n","family":"Ad\u0131g\u00fczel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1371-8399","authenticated-orcid":false,"given":"Ebru","family":"Aypar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tevfik","family":"Karag\u00f6z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6607-0568","authenticated-orcid":false,"given":"\u0130lker","family":"Ertu\u011frul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrettin Hakan","family":"Aykan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dursun","family":"Alehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"G\u00fcvener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Demircin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0131za","family":"Do\u011fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"S1047951124025599_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951113001169"},{"key":"S1047951124025599_ref2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.1.111"},{"key":"S1047951124025599_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1998.tb00113.x"},{"key":"S1047951124025599_ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.619338"},{"key":"S1047951124025599_ref3","first-page":"2699","volume-title":"Heart Disease In Infants, Children, and Adolescents","author":"Cetta","year":"2021"},{"key":"S1047951124025599_ref16","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12404"},{"key":"S1047951124025599_ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951121002353"},{"key":"S1047951124025599_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.04.049"},{"key":"S1047951124025599_ref20","first-page":"17","article-title":"Ebstein\u2019s anomaly. 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