{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T12:10:42Z","timestamp":1750939842795,"version":"3.32.0"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"unspecified","delay-in-days":58,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951124025733_as1\"><jats:title>Background and aims:<\/jats:title><jats:p>Our aim was to investigate all children admitted to paediatric intensive care units (ICU)\u00a0in the Republic of Ireland between January 2020 and August 2022 with an admitting diagnosis of acute COVID-19 infection or paediatric inflammatory multi-system syndrome, temporally associated with SARS-CoV-2 (PIMS-TS) or associated illness. The patients were identified to catalogue the severity of illness, analyse cardiovascular manifestations of their disease, and short-term outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124025733_as2\"><jats:title>Methods:<\/jats:title><jats:p>This is a retrospective multi-centre observational study.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124025733_as3\"><jats:title>Results:<\/jats:title><jats:p>127 children were admitted to paediatric ICU in Ireland with a COVID-19- related illness between January 2020 and August 2022. 87 (68.5%) of patients had acute COVID-19 infection, 39 (30.7%) had PIMS-TS and 1 (0.8%) patient had post-COVID vaccine-related myocarditis. Ventilatory support was required for 47\/87 (54%) in the COVID-19 group comparative to 9\/39 (23%) of patients with PIMS-TS. Inotropic support was required for 13\/87 (14.9%) children with COVID-19 and 29\/39 (74.3%) with PIMS-TS. Evidence of any cardiac disease on ECHO was identified in 23\/38 (60.5%) of the PIMS-TS cohort comparative to only 5\/36 (13.9%) of patients with COVID-19. 38\/39 (97.4%) of patients with PIMS-TS-related cardiac disease and 100% with COVID-19 had a normal echo at the time of discharge from hospital. Overall survival of patients was 100%.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124025733_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>The burden of cardiac disease in children requiring paediatric ICU care for COVID-19-related disease was high in the acute phase; however, all children survived, and all cardiac investigations had normalised by short-term follow-up.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951124025733","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T07:06:47Z","timestamp":1732777607000},"page":"2219-2224","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["COVID-19 and PIMS-TS-related admissions to paediatric intensive care in the Republic of Ireland January 2020 and July 2022 and analysis of cardiovascular manifestations of their disease"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7914-7325","authenticated-orcid":false,"given":"Nicola","family":"McCay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niamh","family":"Beirne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Bereton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Healy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orla","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"S1047951124025733_ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.707650"},{"key":"S1047951124025733_ref14","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.15585\/mmwr.mm6932e2","article-title":"COVID-19\u2013associated multisystem inflammatory syndrome in children \u2014 United States, March\u2013July 2020","volume":"69","author":"S","year":"2020","journal-title":"Morbid Mortal Weekly Rep"},{"volume-title":"JAMA","year":"2020","author":"Freaney","key":"S1047951124025733_ref20"},{"key":"S1047951124025733_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"S1047951124025733_ref6","unstructured":"6. Census of Republin of Ireland Population 2016- Etnicity and Religion. Central statistic office. Cso.ie"},{"key":"S1047951124025733_ref8","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2020-320388"},{"key":"S1047951124025733_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-021-01602-3"},{"key":"S1047951124025733_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951122001251"},{"key":"S1047951124025733_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2022.10.017"},{"key":"S1047951124025733_ref17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10369"},{"key":"S1047951124025733_ref5","unstructured":"5. HSE. Covid-19 Vaccination Uptakei n Irealand Weekly report. Week 29 2022, week ending Sunday 24th July 2022. www.hspc.ie"},{"key":"S1047951124025733_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.056"},{"key":"S1047951124025733_ref2","unstructured":"2. Royal College of Paediatrics and Child Health. Guidance: Paediatric multisystem inflammatory syndrome temporally associated with COVID-19.Royal College of Paediatrics and Child Health 2020, https:\/\/www.rcpch.ac.uk\/sites\/default\/files\/2020-05\/COVID-19-Paediatric-multisystem-%20inflammatory%20syndrome-20200501.pdf."},{"key":"S1047951124025733_ref11","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000484"},{"key":"S1047951124025733_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2021.100075"},{"key":"S1047951124025733_ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"S1047951124025733_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.2091"},{"key":"S1047951124025733_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-020-02391-2"},{"key":"S1047951124025733_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(20)30177-2"},{"key":"S1047951124025733_ref1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12061503"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951124025733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T13:57:52Z","timestamp":1736431072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951124025733\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S1047951124025733"],"URL":"https:\/\/doi.org\/10.1017\/s1047951124025733","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"\u00a9 The Author(s), 2024. 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