{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:03:03Z","timestamp":1784912583161,"version":"3.55.0"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951124025952_as1\"><jats:title>Aim:<\/jats:title><jats:p>This study aims to evaluate the clinical characteristics and outcomes of children diagnosed with sinus node dysfunction.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124025952_as2\"><jats:title>Methods:<\/jats:title><jats:p>This was a retrospective review of patients diagnosed with sinus node dysfunction in two tertiary paediatric cardiology centres in Turkey from January 2011 to June 2022.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124025952_as3\"><jats:title>Results:<\/jats:title><jats:p>In all, 77 patients (50, 64.9% males) were included, with a mean age of 8.2 \u00b1 6.3 years and a mean weight of 28.2 \u00b1 18.8 kg. While age-incompatible bradycardia and pauses were the most common rhythm disturbances, syncope, presyncope, and dizziness (n:33, 43%) were the most frequent initial symptoms. Structural heart disease was present in 58 (75.3%) of the 77 patients, 47 (61%) of whom were congenital. The most commonly associated CHDs were transposition of the great arteries (n:8), atrial septal defect (n:7), and atrioventricular septal defect (n:5). Seven of them also had left atrial isomerism. The remaining 19 patients were isolated. Four patients had SCN5A mutation (two of them were siblings) and two of them had Emery\u2013Dreifuss muscular dystrophy.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124025952_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Although sinus node dysfunction is rare in children, it has been diagnosed with increasing frequency with structural heart disease, especially in patients who have undergone corrective cardiac surgery related to atrial tissue. Since sinus node dysfunction can occur at any time postoperatively, these patients should be kept under constant control. If symptomatic sinus node dysfunction is confirmed, permanent pacing is an effective therapeutic modality.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951124025952","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T13:48:53Z","timestamp":1731937733000},"page":"297-302","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Sinus node dysfunction in children: different aetiologies, similar clinical course in two-centre experience"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4600-8986","authenticated-orcid":false,"given":"Gulhan","family":"Tunca Sahin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8451-1892","authenticated-orcid":false,"given":"Cemil 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