{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:16:58Z","timestamp":1792711018695,"version":"4.5.0"},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951124026581_as1\">\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The functional roles of ventricular dominance and additional ventricular chamber after Fontan operation are still uncertain. We aim to assess and correlate such anatomical features to late clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951124026581_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Fontan patients undergoing cardiac MRI and cardiopulmonary exercise test between January 2020 and December 2022 were retrospectively reviewed. Clinical, cardiac MRI, and cardiopulmonary exercise test data from the last follow-up were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951124026581_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fifty patients were analysed: left dominance was present in 29 patients (58%, median age 20 years, interquartile range:16\u201326). At a median follow-up after the Fontan operation was 16 years (interquartile range: 4\u201342), NYHA classes III and IV was present in 3 patients (6%), 4 (8%) underwent Fontan conversion, 2 (4%) were listed for heart transplantation, and 2 (4%) died. Statistical analysis showed that the additional ventricular chamber was larger (&gt;20 mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) in patients with a right dominant ventricle (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01), and right dominance was associated with a higher incidence of post-operative low-cardiac output syndrome (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.043). Left ventricular dominance was associated with a better ejection fraction (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04), less extent of late gadolinium enhancement (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.022), higher metabolic equivalents (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01), and higher peak oxygen consumption (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.033). A larger additional ventricular chamber was associated with a higher need for post-operative extracorporeal membrane oxygenation support (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007), but it did not influence functional parameters on cardiac MRI or cardiopulmonary exercise test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951124026581_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In Fontan patients, left ventricular dominance correlated to better functional outcomes. Conversely, a larger additional ventricular chamber is more frequent in right ventricular dominance and can negatively affect the early post-Fontan course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951124026581","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T03:01:28Z","timestamp":1730257288000},"page":"126-135","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["The impact of dominant ventricle morphology and additional ventricular chamber size on clinical outcomes in patients with Fontan circulation"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7535-9670","authenticated-orcid":false,"given":"Massimo A.","family":"Padalino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4472-6287","authenticated-orcid":false,"given":"Matteo","family":"Ponzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Reffo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danila","family":"Azzolina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annachiara","family":"Cavaliere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Puricelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Cabrelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Bergonzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8140-6798","authenticated-orcid":false,"given":"Biagio","family":"Castaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimiro","family":"Vida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Di Salvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"S1047951124026581_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezab194"},{"key":"S1047951124026581_ref27","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2018-000902"},{"key":"S1047951124026581_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00244-6"},{"key":"S1047951124026581_ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.748566"},{"key":"S1047951124026581_ref45","article-title":"Tricuspid valve repair can restore the prognosis of patients with hypoplastic left heart syndrome and tricuspid valve regurgitation: a meta-analysis","author":"Ponzoni","year":"2023","journal-title":"Pediatr Cardiol"},{"key":"S1047951124026581_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.10.012"},{"key":"S1047951124026581_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.05.020"},{"key":"S1047951124026581_ref28","doi-asserted-by":"publisher","DOI":"10.1177\/2150135119860382"},{"key":"S1047951124026581_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2021.02.034"},{"key":"S1047951124026581_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90282-X"},{"key":"S1047951124026581_ref43","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.4.330"},{"key":"S1047951124026581_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(95)70237-7"},{"key":"S1047951124026581_ref20","unstructured":"20. 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