{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T15:56:00Z","timestamp":1764431760430,"version":"3.37.3"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"unspecified","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951124026829_as1\"><jats:title>Objectives:<\/jats:title><jats:p>Giant coronary artery aneurysms are rare but potentially fatal complications of Kawasaki disease. The lack of evidence-based recommendations on their management and treatment cause guidelines and practices to differ. We aimed to assess these variations.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124026829_as2\"><jats:title>Methods:<\/jats:title><jats:p>An anonymous online survey regarding surveillance, imaging, pharmacological management, and interventional practices was distributed among 134 physicians attending to Kawasaki disease patients worldwide. A p-value of &lt;0.05 was deemed significant.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124026829_as3\"><jats:title>Results:<\/jats:title><jats:p>The majority (60%) of respondents were general paediatric cardiologists, and 29% interventional specialists. The average years in practice was 15 \u00b1 9.6. Physicians from Asia had the most experience with giant coronary artery aneurysms. American practitioners preferred combining anticoagulants with aspirin. Beta-blockers and statins were more likely used in teenagers versus younger children. Cardiac catheterisation was most (52%) chosen for coronary surveillance in patients with echocardiogram anomalies, followed by Coronary CT-angiography. The indications for coronary intervention were split among respondents, regardless of geographic region or experience. The preferred treatment of coronary stenosis was percutaneous intervention (69%) versus bypass surgery. For thrombosis, thrombolytics (50%) were preferred over percutaneous (39%) and surgical (11%) interventions. Most (92%) preferred intervening in young children in a paediatric facility but were split between a paediatric and adult facility for older children. Most chose combined management by adult and paediatric specialists for either age-scenarios (70, 82%).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124026829_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>As identified by our study, the lack of large studies and evidence-based recommendations cause uncertainty and ambivalence towards certain treatments. International collaborative efforts are needed to provide more robust evidence in the management of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951124026829","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T09:59:56Z","timestamp":1731319196000},"page":"2333-2340","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Variation in the management and treatment of children with giant coronary artery aneurysm following Kawasaki disease"],"prefix":"10.1017","volume":"34","author":[{"given":"Mia","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Dionne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine F.","family":"Choueiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2622-573X","authenticated-orcid":false,"given":"Ashraf S.","family":"Harahsheh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seda","family":"Tierney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u00f1aki","family":"Navarro Castellanos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7715-3169","authenticated-orcid":false,"given":"Nagib","family":"Dahdah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"S1047951124026829_ref19","article-title":"Kawasaki\u2019s sygdom","volume":"5","author":"Mette Holm","year":"2015","journal-title":"Danish Paediatr Soc"},{"key":"S1047951124026829_ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-022-04458-z"},{"key":"S1047951124026829_ref11","doi-asserted-by":"publisher","DOI":"10.1515\/med-2021-0242"},{"key":"S1047951124026829_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306427"},{"key":"S1047951124026829_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key344"},{"key":"S1047951124026829_ref6","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2019-315925"},{"key":"S1047951124026829_ref28","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-08-0931"},{"key":"S1047951124026829_ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-018-0536-3"},{"key":"S1047951124026829_ref17","first-page":"5","article-title":"Enfermedad de kawasaki: consenso interdisciplinario e intersociedades (gu\u00eda pr\u00e1ctica cl\u00ednica)","volume":"114","author":"H\u00e9ctor Abate","year":"2016","journal-title":"Versi\u00f3n abreviada. Sociedad Argentina de Pediatr\u00eda Subcomisiones. 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Lotta Nordenh\u00e4ll, BM . NATIONELLT PM F\u00d6R KAWASAKIS SJUKDOM 2023. VO (barnlakarforeningen.se); last accessed 10 October 2024."},{"key":"S1047951124026829_ref7","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-08-0121"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951124026829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T07:04:53Z","timestamp":1739775893000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951124026829\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S1047951124026829"],"URL":"https:\/\/doi.org\/10.1017\/s1047951124026829","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"\u00a9 The Author(s), 2024. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}