{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T04:10:54Z","timestamp":1742616654533,"version":"3.40.2"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951124036369_as1\"><jats:title>Background:<\/jats:title><jats:p>A subgroup of CHDs can only be treated palliatively through a Fontan circulation. In case of a failing Fontan situation, serum proteins are lost unspecifically and can also lead to a loss of vaccine antibodies. In a failing Fontan situation, heart transplantation may be the only feasible option.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124036369_as2\"><jats:title>Patient:<\/jats:title><jats:p>We describe a 17-year-old patient born with a hypoplastic left heart complex, who underwent Fontan completion at the age of 4 years and developed a failing Fontan physiology. Therefore, a Fontan takedown with creation of a reverse 1\u00bd-circulation was performed. Multiple exacerbations of protein losing enteropathy occurred with a hypoproteinaemia, hypalbuminaemia, and hypogammaglobulinaemia. The patient was hospitalised several times and treated with intravenous application of immunoglobulins and albumin for symptom control. Before one of this substitutions, the immunoglobulin G against measles, mumps, and rubella was determined: the patient\u2019s serum demonstrated a positive measles and rubella, but mumps was negative. After administration of the iv-therapy, the lacking antibodies were replenished, and there was a positive test for mumps.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124036369_as3\"><jats:title>Method:<\/jats:title><jats:p>Serum samples were analysed by neutralisation test and enzyme-linked immunosorbent assay (ELISA).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951124036369_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Although the patient had been vaccinated according to national guidelines, we saw an intermittent immune deficiency for mumps, but not for rubella and measles. For patient with a failing Fontan circulation, we recommend to test to vaccine antibodies for mumps, measles, and rubella with an ELISA an if its negative with a neutralisation test, especially in view of a possible heart transplantation to find a possible immune deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951124036369","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T06:44:08Z","timestamp":1736232248000},"page":"379-381","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Isolated loss of vaccine immunity in the protein losings syndrome in a patient with a reverse one and a half ventricle palliation (\u201cfailing Fontan-like physiology\u201d)"],"prefix":"10.1017","volume":"35","author":[{"given":"Martin","family":"Leroy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8969-834X","authenticated-orcid":false,"given":"Angelika","family":"Weis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7478-5005","authenticated-orcid":false,"given":"David","family":"Backhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Santibanez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Mankertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Jux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"S1047951124036369_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08199-8"},{"key":"S1047951124036369_ref9","unstructured":"9. Rainer Kozlik-Feldmann, SU , zu Knyphausen, Edzard , Dubowy, Karl-Otto , Murin, Peter , Dorka, Raphael. S2k leitlinie herztransplantation im kindes- und jugendalter sowie bei Erwachsenen mit angeborenen herzfehlern 2019."},{"key":"S1047951124036369_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivac173"},{"key":"S1047951124036369_ref10","unstructured":"10. Robert Koch Institute 2024, Epidemiologisches Bulletin, Issue 15\/2024, https:\/\/www.rki.de\/DE\/Content\/Infekt\/EpidBull\/Archiv\/2024\/Ausgaben\/15_24.pdf?blob=publicationFile (accessed 13 April 2024)."},{"key":"S1047951124036369_ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2009.01030.x"},{"key":"S1047951124036369_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjtc.2022.01.020"},{"key":"S1047951124036369_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.07.065"},{"key":"S1047951124036369_ref11","first-page":"270","article-title":"Vaccination gaps of employees in institutions of preschool childcare before introduction of the measles protection act","volume":"85","author":"Stephan Goertz","year":"2023","journal-title":"Gesundheitswesen"},{"key":"S1047951124036369_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.08.110"},{"key":"S1047951124036369_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12368"},{"key":"S1047951124036369_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.04.061"},{"key":"S1047951124036369_ref8","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308848"},{"key":"S1047951124036369_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2009.09.006"},{"key":"S1047951124036369_ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000696"},{"key":"S1047951124036369_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12570"},{"key":"S1047951124036369_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.023"},{"key":"S1047951124036369_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2021.100128"},{"key":"S1047951124036369_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s12055-020-00931-2"},{"key":"S1047951124036369_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.04.071"},{"key":"S1047951124036369_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.09.028"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951124036369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T10:17:26Z","timestamp":1742552246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951124036369\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S1047951124036369"],"URL":"https:\/\/doi.org\/10.1017\/s1047951124036369","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2025,1,7]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}