{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:09:03Z","timestamp":1777410543827,"version":"3.51.4"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951125000381_as1\"><jats:title>Objectives:<\/jats:title><jats:p>To demonstrate safety and efficacy of using the Amplatzer<jats:sup>TM<\/jats:sup> vascular plug II device for perimembranous ventricular septal defect closure with retrograde approach and show the follow-up in all patients.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951125000381_as2\"><jats:title>Background:<\/jats:title><jats:p>At present, there is no FDA-approved device for transcatheter closure of perimembranous ventricular septal defects. Small studies and case reports have shown the use of various catheter-based devices in an off-label management; however, there are no large studies to show their efficacy. The second generation of Amplatzer<jats:sup>TM<\/jats:sup> vascular plug seems to offer a safe and attractive alternative for this procedure. Besides, a retrograde approach might decrease procedure time and radiation exposure time.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951125000381_as3\"><jats:title>Methods and Results:<\/jats:title><jats:p>Patients with congenital perimembranous ventricular septal defects who underwent transcatheter closure using Amplatzer vascular plug II devices were included. Primary end point was to determine efficacy and safety of this generation of devices and the incidence of complications at follow-up (complete heart block and aortic\/tricuspid\/mitral regurgitation). Forty-five patients underwent perimembranous ventricular septal defect closure at a median age of 6 years (9 months\u201317 years). During the catheterization, there were only minor complications and at follow-up of 48 \u00b1 25.7 months (up to 96 months). Closure rate was high of 93.3% and freedom from atrioventricular block was 100%.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951125000381_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>The second generation of the Amplatzer<jats:sup>TM<\/jats:sup> vascular plug II seems to offer a safe and attractive alternative for percutaneous closure of the perimembranous ventricular septal defects.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951125000381","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T08:53:06Z","timestamp":1740387186000},"page":"683-687","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Closure of perimembranous ventricular septal defects using the Amplatzer vascular plug II: experience of a Mexican centre"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0817-3139","authenticated-orcid":false,"given":"Roberto","family":"Mijangos-V\u00e1zquez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogelio","family":"Hern\u00e1ndez-Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"S1047951125000381_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90903-3"},{"key":"S1047951125000381_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(86)90114-2"},{"key":"S1047951125000381_ref11","first-page":"941","article-title":"Percutaneous closure of perimembranous ventricular septal defects with amplatzer occluders\u2014a single-center experience","volume":"66","author":"Szkutnik","year":"2008","journal-title":"Kardiol Pol"},{"key":"S1047951125000381_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(96)01058-5"},{"key":"S1047951125000381_ref1","first-page":"298","volume-title":"Ventricular septal defect","author":"Mavroudis","year":"2003"},{"key":"S1047951125000381_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.10.010"},{"key":"S1047951125000381_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.09.068"},{"key":"S1047951125000381_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-726X(200002)49:2<167::AID-CCD11>3.0.CO;2-S"},{"key":"S1047951125000381_ref18","doi-asserted-by":"publisher","DOI":"10.1583\/05-1505MR.1"},{"key":"S1047951125000381_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.23074"},{"key":"S1047951125000381_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(03)00430-5"},{"key":"S1047951125000381_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-007-9044-3"},{"key":"S1047951125000381_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90380-8"},{"key":"S1047951125000381_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115002206"},{"key":"S1047951125000381_ref17","first-page":"324","article-title":"Retrograde transcatheter closure of perimembranous aneurysmal ventricular septal defects using amplatzer vascular plug II","volume":"2","author":"Shokka","year":"2019","journal-title":"J Med Sci Res"},{"key":"S1047951125000381_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.10.047"},{"key":"S1047951125000381_ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8183.2003.08006.x"},{"key":"S1047951125000381_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.10797"},{"key":"S1047951125000381_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-005-0160-7"},{"key":"S1047951125000381_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-004-0857-4"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125000381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T04:02:26Z","timestamp":1743566546000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125000381\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S1047951125000381"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125000381","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. 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