{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T11:00:33Z","timestamp":1775905233716,"version":"3.50.1"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125001209_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Passive leg raising is used to predict who will benefit from fluid therapy in critically ill patients, including children. Patients with a Fontan circulation may have a different haemodynamic response to a fluid challenge by passive leg raising.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001209_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The haemodynamic response of 31 paediatric patients with a Fontan circulation from the outpatient clinic (median age 14.0 years) and 35 healthy controls (median age 12.8 years) to passive leg raising was evaluated non-invasively by echocardiography for the assessment of, e.g., velocity time integral across the (neo)aortic valve, blood pressure measurements, and respiration. Participants were considered responders when the velocity time integral increased \u2265 10.0%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001209_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Overall, patients and controls did not differ in the haemodynamic response. Twelve patients (38.7%) and 8 controls (22.9%) were responders, which was not statistically different (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.22). Responders in the patient and control group also had a similar echo-estimated velocity time integral increase of + 18.9% and + 15.2%, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.91). There was no difference in echo-estimated velocity time integral change between patient and control non-responders with a decrease of \u22121.4% and \u22126.4%, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.70) and no difference in the amount of patients who were negatively affected by passive leg raising, ith a decrease of \u2264\u221210.0% in 7 patients (22.6%) and 9 controls (25.7%)(\n                      <jats:italic>P<\/jats:italic>\n                      = 0.77).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001209_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The haemodynamic response of ambulatory paediatric patients with a Fontan circulation to passive leg raising is like that of healthy controls. Patients who did not respond were similarly affected as healthy controls. Whether the haemodynamic response is different in critically ill patients warrants further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001209_as5\">\n                    <jats:title>Trail registration:<\/jats:title>\n                    <jats:p>The Netherlands National Trial Register (NTR), Trial: NL6415; date of registration 20-07-2017; Trial information: https:\/\/www.trialregister.nl\/trial\/6415.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125001209","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T04:37:57Z","timestamp":1742186277000},"page":"938-943","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Fluid responsiveness of ambulatory paediatric patients with a Fontan circulation by passive leg raising"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1930-013X","authenticated-orcid":false,"given":"Lisette M.","family":"Harteveld","sequence":"first","affiliation":[{"name":"The Centre for Congenital Heart Disease Amsterdam\u2013Leiden"},{"name":"Leiden University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4823-6974","authenticated-orcid":false,"given":"Nico A.","family":"Blom","sequence":"additional","affiliation":[{"name":"The Centre for Congenital Heart Disease Amsterdam\u2013Leiden"},{"name":"Leiden University Medical Centre"},{"name":"Amsterdam University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8916-6231","authenticated-orcid":false,"given":"J. Gert","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7784-1807","authenticated-orcid":false,"given":"Robert H.A.M.","family":"Reijntjes","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"van Someren","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8588-3273","authenticated-orcid":false,"given":"Fabian I.","family":"Kerkhof","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8960-0859","authenticated-orcid":false,"given":"Irene M.","family":"Kuipers","sequence":"additional","affiliation":[{"name":"The Centre for Congenital Heart Disease Amsterdam\u2013Leiden"},{"name":"Amsterdam University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7529-4195","authenticated-orcid":false,"given":"Lukas A.J.","family":"Rammeloo","sequence":"additional","affiliation":[{"name":"The Centre for Congenital Heart Disease Amsterdam\u2013Leiden"},{"name":"Amsterdam University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3016-1086","authenticated-orcid":false,"given":"Arend D.J.","family":"ten Harkel","sequence":"additional","affiliation":[{"name":"The Centre for Congenital Heart Disease Amsterdam\u2013Leiden"},{"name":"Leiden University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"S1047951125001209_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12560"},{"key":"S1047951125001209_ref8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.6.2000"},{"key":"S1047951125001209_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-013-1303-5"},{"key":"S1047951125001209_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4306-7"},{"key":"S1047951125001209_ref9","doi-asserted-by":"publisher","DOI":"10.1080\/AC.70.5.3110514"},{"key":"S1047951125001209_ref4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4103\/1687-9090.183222","article-title":"Monitoring the correlation between passive leg-raising maneuver and fluid challenge in pediatric cardiac surgery patients using impedance cardiography","volume":"10","author":"Labib","year":"2016","journal-title":"Egypt J Anaesth Cardiothorac Anesthesia"},{"key":"S1047951125001209_ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1796-9"},{"key":"S1047951125001209_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000215453.11735.06"},{"key":"S1047951125001209_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2021.08.012"},{"key":"S1047951125001209_ref15","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2009.218594"},{"key":"S1047951125001209_ref13","doi-asserted-by":"publisher","DOI":"10.1186\/cc6822"},{"key":"S1047951125001209_ref6","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.IJPVM_11_17"},{"key":"S1047951125001209_ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-020-00679-3"},{"key":"S1047951125001209_ref12","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2017-206836"},{"key":"S1047951125001209_ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-6-3"},{"key":"S1047951125001209_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3182388ab3"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125001209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:29:42Z","timestamp":1775903382000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125001209\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,17]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1047951125001209"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125001209","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,17]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}