{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T04:02:00Z","timestamp":1743652920707,"version":"3.40.3"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951125001222_as1\"><jats:title>Background:<\/jats:title><jats:p>Acquired chylothorax is an established complication of CHD surgery, affecting 2\u20139% of patients. CHD places a child at risk for failure to thrive, with subsequent chylothorax imposing additional risk.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951125001222_as2\"><jats:title>Objective:<\/jats:title><jats:p>We conducted a retrospective chart review to ascertain quantitative markers of nutrition and growth in children affected by chylothorax following CHD surgery between 2018 and 2022 compared to controls.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951125001222_as3\"><jats:title>Methods:<\/jats:title><jats:p>We utilised electronic medical record system, EPIC, at Children\u2019s Hospital, New Orleans, targeting subjects &lt; 18 years old who underwent CHD surgery between 2018 and 2022 and developed a subsequent chylothorax. Study subjects were identified using the 10th revision of the International Classification of Diseases codes (ICD-10 codes: J94.0, I89.8, and J90.0). Each chylothorax case (<jats:italic>n<\/jats:italic> = 20) was matched by procedure type and age to a control with no chylothorax (<jats:italic>n<\/jats:italic> = 20). Data were recorded in REDCap and analysed using SPSS.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951125001222_as4\"><jats:title>Results:<\/jats:title><jats:p>After removal of outliers, we analysed 19 total matched pairs. There was no statistical difference in growth velocity (<jats:italic>p<\/jats:italic> = 0.12), weight change (operation to discharge) (<jats:italic>p<\/jats:italic> = 0.95), weight change (admission to discharge) (<jats:italic>p<\/jats:italic> = 0.35), Z-score change (operation to discharge) (<jats:italic>p<\/jats:italic> = 0.90), Z-score change (admission to discharge) (<jats:italic>p<\/jats:italic> = 0.21), serum protein (<jats:italic>p<\/jats:italic> = 0.88), or serum albumin (<jats:italic>p<\/jats:italic> = 0.82). Among cases, linear regression demonstrated no significant association between maximum chylous output and growth velocity (<jats:italic>p<\/jats:italic> = 0.91), weight change (operation to discharge) (<jats:italic>p<\/jats:italic> = 0.15), or weight change (admission to discharge) (<jats:italic>p<\/jats:italic> = 0.98).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951125001222_as5\"><jats:title>Conclusions:<\/jats:title><jats:p>We did not observe statistically significant markers of growth or nutrition in children with chylothorax post-CHD surgery compared to those without chylothorax. Multisite data collection and analysis is required to better ascertain clinical impact and guide clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951125001222","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T09:14:44Z","timestamp":1740993284000},"page":"791-797","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Markers of growth and nutrition in children with acquired chylothorax post CHD surgery"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7343-6110","authenticated-orcid":false,"given":"Kevin N.","family":"Marzotto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin R.","family":"Videlefsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan P.","family":"Howell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Kimball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank A.","family":"Pigula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9491-561X","authenticated-orcid":false,"given":"Kurt D.","family":"Piggott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"S1047951125001222_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"S1047951125001222_ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-019-02134-y"},{"key":"S1047951125001222_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2020.05.001"},{"key":"S1047951125001222_ref28","doi-asserted-by":"publisher","DOI":"10.1177\/2150135121991528"},{"key":"S1047951125001222_ref24","doi-asserted-by":"publisher","DOI":"10.1136\/adc.81.1.49"},{"key":"S1047951125001222_ref4","doi-asserted-by":"publisher","DOI":"10.4067\/S0370-41062018000100024"},{"key":"S1047951125001222_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.09.068"},{"key":"S1047951125001222_ref32","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31819371f6"},{"key":"S1047951125001222_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.05.058"},{"key":"S1047951125001222_ref20","first-page":"586","article-title":"Retinol-binding 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