{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T11:00:31Z","timestamp":1775905231762,"version":"3.50.1"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125001362_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Aortic coarctation can occur isolated or associated with ventricular septal defect. This study evaluated aortic stiffness in normotensive patients surgically treated for aortic coarctation and ventricular septal defect and in those who underwent simple aortic coarctation repair. Both groups were compared with healthy controls. Again, the two pathological groups were compared with each other regarding aortic stiffness and left ventricular diastolic function. A possible relationship between aortic stiffness and left ventricular diastolic function was investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001362_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty-two isolated aortic coarctation patients and 17 aortic coarctation and ventricular septal defect patients were enrolled. Aortic root distensibility and aortic stiffness index were calculated from echocardiography and blood pressure. E wave to A wave (E\/A) ratio was measured from mitral valve inflow profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001362_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Aortic root distensibility and aortic stiffness index in simple aortic coarctation vs healthy controls: both\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001. Aortic root distensibility and aortic stiffness index in aortic coarctation\/ventricular septal defect vs healthy controls: both\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001. Aortic root distensibility and aortic stiffness index were similar in the two pathological groups (both\n                      <jats:italic>p<\/jats:italic>\n                      = ns). No statistically significant difference was detected in relation to left ventricular diastolic function (\n                      <jats:italic>p<\/jats:italic>\n                      = ns). No correlation was detected between aortic stiffness and diastolic function in simple aortic coarctation and aortic coarctation\/ventricular septal defect groups (both\n                      <jats:italic>p<\/jats:italic>\n                      = ns).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001362_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In both normotensive isolated aortic coarctation and aortic coarctation\/ventricular septal defects subgroups, aortic stiffness is increased in a similar way in comparison with controls. Diastolic function was normal and similar in both groups. Aortic stiffness was not related to left ventricular diastolic function in this specific setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125001362","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T07:04:33Z","timestamp":1742972673000},"page":"985-989","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Aortic stiffness assessed by blood pressure and echocardiography in young and normotensive patients with isolated aortic coarctation versus those with aortic coarctation and ventricular septal defect"],"prefix":"10.1017","volume":"35","author":[{"given":"Sophie","family":"Duignan","sequence":"first","affiliation":[{"name":"Children\u2019s Health Ireland at Crumlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8374-4280","authenticated-orcid":false,"given":"Michaela","family":"Pentony","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Ireland at Crumlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin Patrick","family":"Walsh","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Ireland at Crumlin"},{"name":"Mater Misericordiae University Hospital"},{"name":"University College of Dublin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-9338","authenticated-orcid":false,"given":"Colin Joseph","family":"McMahon","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Ireland at Crumlin"},{"name":"University College of Dublin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8374-0260","authenticated-orcid":false,"given":"Pier Paolo","family":"Bassareo","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Ireland at Crumlin"},{"name":"Mater Misericordiae University Hospital"},{"name":"University College of Dublin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"S1047951125001362_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059639"},{"key":"S1047951125001362_ref23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.4.689"},{"key":"S1047951125001362_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.07.052"},{"key":"S1047951125001362_ref8","first-page":"279","article-title":"Relationship between left ventricular diastolic function and arterial stiffness in patients with bicuspid aortic valve","volume":"23","author":"Kocabay","year":"2014","journal-title":"J Heart Valve Dis"},{"key":"S1047951125001362_ref14","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2013.113"},{"key":"S1047951125001362_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(86)90116-6"},{"key":"S1047951125001362_ref28","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2013.43.4.215"},{"key":"S1047951125001362_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-008-9381-2"},{"key":"S1047951125001362_ref7","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2018.1530084"},{"key":"S1047951125001362_ref15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1904"},{"key":"S1047951125001362_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2019.03.002"},{"key":"S1047951125001362_ref31","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-200209000-00001"},{"key":"S1047951125001362_ref25","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1069"},{"key":"S1047951125001362_ref6","volume-title":"Genetic and environmental risk factors of major cardiovascular malformations: the Baltimore-Washington Infant Study 1981\u20131989","author":"Ferencz","year":"1997"},{"key":"S1047951125001362_ref10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006651"},{"key":"S1047951125001362_ref2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.46.3.269"},{"key":"S1047951125001362_ref21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1055\/s-0040-1714384","article-title":"Abnormal aortic wall properties in women with turner syndrome","volume":"8","author":"Bons","year":"2020","journal-title":"Aorta (Stamford)"},{"key":"S1047951125001362_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(71)90259-1"},{"key":"S1047951125001362_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.49.5.485"},{"key":"S1047951125001362_ref4","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.50.2.176"},{"key":"S1047951125001362_ref5","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.49.61"},{"key":"S1047951125001362_ref26","first-page":"881","article-title":"Does oxygen content play a role in spontaneous closure of perimembranous ventricular septal defects?","volume":"8","author":"Bassareo","year":"2021","journal-title":"Children (Basel)"},{"key":"S1047951125001362_ref30","first-page":"100530","article-title":"Increased prevalence of left ventricular diastolic dysfunction in adults with repaired coarctation of aorta","volume":"28","author":"Egbe","year":"2020","journal-title":"Int J Cardiol Heart Vasc"},{"key":"S1047951125001362_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(20)31432-X"},{"key":"S1047951125001362_ref16","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13010028"},{"key":"S1047951125001362_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12350"},{"key":"S1047951125001362_ref32","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.661983"},{"key":"S1047951125001362_ref13","first-page":"100335","article-title":"Imaging of ventricular septal defect: native and post-repair","volume":"7","author":"Fusco","year":"2022","journal-title":"Int J Cardiol Congenit Heart Dis"},{"key":"S1047951125001362_ref17","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000001432"},{"key":"S1047951125001362_ref20","doi-asserted-by":"publisher","DOI":"10.23736\/S0392-9590.16.03327-7"},{"key":"S1047951125001362_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.6.2259"},{"key":"S1047951125001362_ref27","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-10-48"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125001362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:29:38Z","timestamp":1775903378000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125001362\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1047951125001362"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125001362","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,26]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}