{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T11:00:35Z","timestamp":1775905235953,"version":"3.50.1"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125001386_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the outcomes of patients with single ventricle physiology supported with extracorporeal membrane oxygenation as a bridge to first-stage palliation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001386_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a retrospective registry-based study. Data from the Extracorporeal Life Support Organization registry were used to identify single ventricle physiology patients supported with extracorporeal membrane oxygenation prior to palliation from 2016 to 2021. Descriptive statistics and multivariate analyses for associations with mortality were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001386_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Primary outcome was death before hospital discharge. Patient characteristics including demographics and associated complications were evaluated as secondary outcomes. Sixty-five patients met inclusion criteria. Survival to discharge was 42%. Twenty-four (37%) patients died while on extracorporeal membrane oxygenation. There was no significant difference in demographics between survivors and non-survivors. Non-survivors had a significantly longer median duration on extracorporeal membrane oxygenation compared to survivors, 99-hrs [IQR (Interquartile Range), 160, 300] vs. 59-hrs [43, 124] (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001). Multivariate analysis demonstrated extracorporeal membrane oxygenation duration (adjusted-OR [Odds Ratio] 1.01, 95% CI [Confidence Interval] 0.98, 0.99;\n                      <jats:italic>p = 0.03<\/jats:italic>\n                      ) and requiring renal replacement therapy (42% vs. 19%;\n                      <jats:italic>p = 0.04<\/jats:italic>\n                      ) were associated with mortality prior to discharge.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001386_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Clinicians managing decompensated patients with single ventricle physiology may consider extracorporeal membrane oxygenation as a bridge to palliation. Survival to discharge was 42%. Evidence of renal injury and longer extracorporeal membrane oxygenation durations were associated with mortality. These data may be used to guide providers and to counsel families. However, more data are needed to refine indications and assess associations related to outcomes and decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125001386","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T06:25:56Z","timestamp":1742538356000},"page":"990-995","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Extracorporeal membrane oxygenation: a bridge to palliation in single ventricle physiology"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7895-8142","authenticated-orcid":false,"given":"Ivana","family":"Capin","sequence":"first","affiliation":[{"name":"Icahn School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Ofori-Amanfo","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Esperanza","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghav","family":"Murthy","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline M.","family":"Lamour","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristi","family":"Glotzbach","sequence":"additional","affiliation":[{"name":"University of Utah School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott I.","family":"Aydin","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"S1047951125001386_ref1","doi-asserted-by":"publisher","DOI":"10.1177\/2150135113507292"},{"key":"S1047951125001386_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000616"},{"key":"S1047951125001386_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.06.074"},{"key":"S1047951125001386_ref11","article-title":"Outcome-associated factors in pediatric patients treated with extracorporeal membrane oxygenator after cardiac surgery","volume":"94","author":"Kulik","year":"1996","journal-title":"Circulation"},{"key":"S1047951125001386_ref3","article-title":"Extracorporeal membrane oxygenation (ECMO) support in special patient populations-the bidirectional Glenn and fontan circulations","volume":"6","author":"Bacon","year":"2014","journal-title":"Front Pediatr"},{"key":"S1047951125001386_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-016-1483-7"},{"key":"S1047951125001386_ref5","first-page":"11","article-title":"Characterization of extracorporeal membrane oxygenation support for single ventricle patients","author":"Stephens","year":"2020","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"S1047951125001386_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.09.075"},{"key":"S1047951125001386_ref12","unstructured":"12. Aydin, SI , Duffy, M , Rodriguez, D , et\u00a0al. Abstract 20424: Extracorporeal Membrane Oxygenation (ECMO) Support in Single Ventricle Patients After the Glenn Procedure: Review of the Extracorporeal Life Support Organization (ELSO) Registry. 2014"},{"key":"S1047951125001386_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.02.023"},{"key":"S1047951125001386_ref19","first-page":"380","article-title":"Extracorporeal membrane oxygenation in congenital heart disease","volume":"9","author":"Perry","year":"2022","journal-title":"Children (Basel"},{"key":"S1047951125001386_ref10","doi-asserted-by":"publisher","DOI":"10.1177\/0391398819876294"},{"key":"S1047951125001386_ref17","article-title":"Extracorporeal membrane oxygenation in children after cardiac surgery","volume":"86","author":"Raithel","year":"1992","journal-title":"Circulation"},{"key":"S1047951125001386_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000603"},{"key":"S1047951125001386_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.05.056"},{"key":"S1047951125001386_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-022-05708-w"},{"key":"S1047951125001386_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01330-8"},{"key":"S1047951125001386_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.03.007"},{"key":"S1047951125001386_ref16","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000119425.04364.CF"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125001386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:29:45Z","timestamp":1775903385000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125001386\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1047951125001386"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125001386","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}