{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T11:00:38Z","timestamp":1775905238811,"version":"3.50.1"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125001453_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neurodevelopmental disorders occur in up to 50% of children with CHD. Small head circumference at birth has been associated with impaired neurodevelopment in patients with complex CHD. It is unknown if patients with simple CHD such as septal defects have smaller head circumferences. The objective of this study was to investigate the head circumference at birth in neonates with either an atrial or a ventricular septal defect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001453_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study is part of the Copenhagen Baby Heart Study; a prospective, population-based cohort study of more than 25,000 neonates. The neonates were examined with a comprehensive transthoracic echocardiography within the first 30 days of birth including assessment for atrial or ventricular septal defects. The head circumference at birth in term neonates with septal defects was compared to the head circumference in matched controls, term neonates without septal defects from the same birth cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001453_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Neonates with septal defects (\n                      <jats:italic>n<\/jats:italic>\n                      = 1,030; 45.2% male; mean birthweight 3,534g \u00b1 483g) had a mean head circumference of 34.8 cm (95%\u00a0confidence interval 34.7\u201334.9 cm), compared to neonates without septal defects (\n                      <jats:italic>n<\/jats:italic>\n                      = 5,150; 45.6% male; mean birthweight 3,546g \u00b1 476g) of 34.7 cm (95% confidence interval 34.7\u201334.8 cm);\n                      <jats:italic>p<\/jats:italic>\n                      -value 0.07. Mean calculated\n                      <jats:italic>z<\/jats:italic>\n                      -score of head circumferences was 0.05 for neonates with septal defects and \u20130.01 for neonates without septal defects,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.07. Dividing cases into neonates with atrial septal defects, ventricular septal defects, and those without septal defects did not show differences between groups,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.14.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001453_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The head circumference in term neonates with septal defects did not differ from matched controls without septal defects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125001453","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T02:37:11Z","timestamp":1745203031000},"page":"915-920","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Head circumference in neonates with septal defects"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4152-1771","authenticated-orcid":false,"given":"Line","family":"H\u00f8ffner","sequence":"first","affiliation":[{"name":"Copenhagen University Hospital Rigshospitalet"},{"name":"University of Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Dehn","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Rigshospitalet"},{"name":"University of Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9997-1514","authenticated-orcid":false,"given":"Sofie","family":"Dannesbo","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Herlev"},{"name":"University of Copenhagen"},{"name":"Copenhagen University Hospital Rigshospitalet"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Blixenkrone-M\u00f8ller","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Herlev"},{"name":"University of Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Lind","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Herlev"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Axelsson","family":"Raja","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Rigshospitalet"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7993-1016","authenticated-orcid":false,"given":"Anne-Sophie","family":"Sillesen","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Herlev"},{"name":"Copenhagen University Hospital Rigshospitalet"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Pihl","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Herlev"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Maagaard","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Rigshospitalet"},{"name":"University of Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels Grove","family":"Vejlstrup","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Rigshospitalet"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasper","family":"Iversen","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Herlev"},{"name":"University of Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"University of Copenhagen"},{"name":"Copenhagen University Hospital Rigshospitalet"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibeke","family":"Hjortdal","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Rigshospitalet"},{"name":"University of Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"S1047951125001453_ref13","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.015843"},{"key":"S1047951125001453_ref23","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.43.3.332"},{"key":"S1047951125001453_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.11.033"},{"key":"S1047951125001453_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.04.047"},{"key":"S1047951125001453_ref35","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018580"},{"key":"S1047951125001453_ref31","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008771"},{"key":"S1047951125001453_ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.786638"},{"key":"S1047951125001453_ref32","doi-asserted-by":"publisher","DOI":"10.1007\/BF00144842"},{"key":"S1047951125001453_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0356-1"},{"key":"S1047951125001453_ref33","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019089"},{"key":"S1047951125001453_ref6","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.109152"},{"key":"S1047951125001453_ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0593-3"},{"key":"S1047951125001453_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-006-1450-9"},{"key":"S1047951125001453_ref20","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyab147"},{"key":"S1047951125001453_ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.947002"},{"key":"S1047951125001453_ref36","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.020915"},{"key":"S1047951125001453_ref34","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13373"},{"key":"S1047951125001453_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.08.041"},{"key":"S1047951125001453_ref22","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951122003365"},{"key":"S1047951125001453_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.02.042"},{"key":"S1047951125001453_ref15","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318265ee8a"},{"key":"S1047951125001453_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12808"},{"key":"S1047951125001453_ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067393"},{"key":"S1047951125001453_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.10.025"},{"key":"S1047951125001453_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0448-y"},{"key":"S1047951125001453_ref16","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36735"},{"key":"S1047951125001453_ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-002-0404-0"},{"key":"S1047951125001453_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2007.12.013"},{"key":"S1047951125001453_ref4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1282"},{"key":"S1047951125001453_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.4.436"},{"key":"S1047951125001453_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"S1047951125001453_ref25","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.865568"},{"key":"S1047951125001453_ref17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.2.402"},{"key":"S1047951125001453_ref27","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14677"},{"key":"S1047951125001453_ref29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83690-3"}],"container-title":["Cardiology 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}