{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T11:00:37Z","timestamp":1775905237807,"version":"3.50.1"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"unspecified","delay-in-days":7,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125001635_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Mechanical circulatory support, and specifically extra-corporeal membrane oxygenation, plays a critical role in managing paediatric cardiac patients with severe heart failure. Whilst these technologies are vital for bridging patients to recovery or heart transplantation, it is imperative to study the influence of extra-corporeal membrane oxygenation on neurodevelopmental outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001635_as2\">\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This systematic review aimed to evaluate the influence of extra-corporeal membrane oxygenation on neurodevelopmental outcomes in paediatric cardiac patients, both post-cardiotomy and non-cardiotomy patients were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001635_as3\">\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>A comprehensive search was conducted using PubMed, EMBASE, and PsychInfo to identify primary research articles exploring the effects of extra-corporeal membrane oxygenation on neurodevelopmental outcomes in paediatric heart patients from inception to June 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001635_as4\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Our search yielded 5488 papers of which eight papers were included featuring 302 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001635_as5\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The discussion highlights the considerable variability in neurodevelopmental outcomes and how they are measured among extra-corporeal membrane oxygenation survivors. Outcomes vary by patient factors, with recovery potential influenced by the duration and timing of follow-up. We emphasised the importance of standardised assessment tools and extended follow-ups to gain a clearer understanding of these outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125001635","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T03:07:52Z","timestamp":1746673672000},"page":"888-899","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the influence of extra-corporeal membrane oxygenation (ECMO) support on neurodevelopmental outcomes in paediatric cardiac patients: a systematic review"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8017-8727","authenticated-orcid":false,"given":"Jeevan","family":"Francis","sequence":"first","affiliation":[{"name":"Aberdeen Royal Infirmary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwini","family":"Chandiramani","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"George","sequence":"additional","affiliation":[{"name":"Aberdeen Royal Infirmary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"George","sequence":"additional","affiliation":[{"name":"Birmingham Women\u2019s and Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Jones","sequence":"additional","affiliation":[{"name":"Birmingham Women\u2019s and Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"S1047951125001635_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000603"},{"key":"S1047951125001635_ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000475"},{"key":"S1047951125001635_ref21","unstructured":"21. NHS. Congenital Heart Disease Standards & Specifications. 2016. [online] Available at: https:\/\/www.england.nhs.uk\/wp-content\/uploads\/2018\/08\/Congenital-heart-disease-standards-and-specifications.pdf."},{"key":"S1047951125001635_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.02.009"},{"key":"S1047951125001635_ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.5323"},{"key":"S1047951125001635_ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-024-04564-x"},{"key":"S1047951125001635_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-019-02115-1"},{"key":"S1047951125001635_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)01194-7"},{"key":"S1047951125001635_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.16110"},{"key":"S1047951125001635_ref17","doi-asserted-by":"publisher","DOI":"10.3171\/2011.1.PEDS10443"},{"key":"S1047951125001635_ref14","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.6.e671"},{"key":"S1047951125001635_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951123000057"},{"key":"S1047951125001635_ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.17714"},{"key":"S1047951125001635_ref4","doi-asserted-by":"publisher","DOI":"10.3310\/hsdr08300"},{"key":"S1047951125001635_ref5","unstructured":"5. James Lind Alliance. congenital heart disease top 10 priorities, National Institute for Health Research. 2023. https:\/\/www.jla.nihr.ac.uk\/priority-setting-partnerships\/congenital-heart-disease\/top-10-priorities.htm."},{"key":"S1047951125001635_ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1131361"},{"key":"S1047951125001635_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001525"},{"key":"S1047951125001635_ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2013.00047"},{"key":"S1047951125001635_ref2","doi-asserted-by":"publisher","DOI":"10.1177\/21501351241268543"},{"key":"S1047951125001635_ref3","unstructured":"3. National Congenital Heart Disease Audit (NCHDA) NICOR. Available at: 2024. https:\/\/www.nicor.org.uk\/national-cardiac-audit-programme\/congenital-audit-nchda."},{"key":"S1047951125001635_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-018-3999-z"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125001635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:29:51Z","timestamp":1775903391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125001635\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1047951125001635"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125001635","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. 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