{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:59:50Z","timestamp":1781182790692,"version":"3.54.1"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125001763_as1\">\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To assess short- and medium-term outcomes of VenusP-valve implantation in the pulmonary position in the paediatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001763_as2\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Percutaneous pulmonary valve implantation is now an established alternative to surgical pulmonary valve replacement, especially in those with conduits in the right ventricular outflow tract. The VenusP-valve\u2122 (Venus Medtech, Shanghai, China) has demonstrated early efficacy in the adult population with larger conduit-free right ventricular outflow tracts. However, its use in children has not been well described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001763_as3\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective review of patients under 18 years of age undergoing VenusP-valve implantation at a single institution between June 2015 and February 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001763_as4\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fifteen patients under the age of 18 years underwent VenusP-valve\u2122 implantation. All had severe pulmonary regurgitation and fulfilled accepted criteria for pulmonary valve implantation. Mean age at valve implantation was 14.1 (range 9.8\u201317.9) years, and mean weight was 54.9 (34.0\u201398.5) kg. The valve was deployed successfully in all the patients. The valve diameter and length ranged between 28\u201336 mm and 25\u201335 mm, respectively. Mean follow-up was 3.4 (0.5\u20138.1) years. At follow-up, twelve patients have undergone magnetic resonance imaging MRI as part of the regular surveillance. Indexed right ventricular end-diastolic volume improved from 157.8 (140.0\u2013197.0) ml\/m\n                      <jats:sup>2<\/jats:sup>\n                      to 117.6 (91.0\u2013152.0) ml\/m\n                      <jats:sup>2<\/jats:sup>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004). Pulmonary regurgitation fraction had reduced from a mean of 44.3 (31.0\u201360.0) % to 3.6 (0.0\u201315.0) % (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125001763_as5\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study demonstrates the safety and feasibility of the VenusP-valve implantation in children. Medium-term follow-up suggests that valve implantation is associated with a reduction in the degree of pulmonary regurgitation and right ventricular end-diastolic volume.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125001763","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T06:49:08Z","timestamp":1747118948000},"page":"1145-1153","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Percutaneous VenusP-valve implantation in the paediatric population"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7303-5808","authenticated-orcid":false,"given":"Mohammad Ryan","family":"Abumehdi","sequence":"first","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Jones","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naychi","family":"Lwin","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Yong","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3030-9749","authenticated-orcid":false,"given":"Eric","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0964-0659","authenticated-orcid":false,"given":"Shakeel","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"S1047951125001763_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29865"},{"key":"S1047951125001763_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.06.039"},{"key":"S1047951125001763_ref36","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.121.011480"},{"key":"S1047951125001763_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad483"},{"key":"S1047951125001763_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad663"},{"key":"S1047951125001763_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.03.002"},{"key":"S1047951125001763_ref37","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jead260"},{"key":"S1047951125001763_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.07.040"},{"key":"S1047951125001763_ref14","first-page":"587","article-title":"The adaptability of the pulsta valve to the diverse main pulmonary artery shape of native right ventricular outflow tract disease","volume":"103","author":"Park","year":"2024","journal-title":"Catheter Cardiovasc Interv"},{"key":"S1047951125001763_ref33","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.674259"},{"key":"S1047951125001763_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.05.050"},{"key":"S1047951125001763_ref29","article-title":"Ventricular arrhythmias following balloon-expandable transcatheter pulmonary valve replacement in the native right ventricular outflow tract","author":"Barfuss","year":"2023","journal-title":"Catheter Cardiovasc Interv Off J Soc Card Angiogr Interv"},{"key":"S1047951125001763_ref32","first-page":"359","article-title":"Five-year follow-up after percutaneous pulmonary valve implantation using the venus P-valve system for patients with pulmonary regurgitation and an enlarged native right ventricular outflow tract","volume":"103","author":"Jin","year":"2024","journal-title":"Catheter Cardiovasc Interv"},{"key":"S1047951125001763_ref26","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/5728998"},{"key":"S1047951125001763_ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008320"},{"key":"S1047951125001763_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.1029"},{"key":"S1047951125001763_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2015.02.014"},{"key":"S1047951125001763_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa554"},{"key":"S1047951125001763_ref28","first-page":"766","article-title":"Ventricular arrhythmias following transcatheter pulmonary valve replacement with the harmony TPV25 device","volume":"100","author":"Taylor","year":"2022","journal-title":"Catheter Cardiovasc Interv Off J Soc Card Angiogr Interv"},{"key":"S1047951125001763_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115001067"},{"key":"S1047951125001763_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.04.018"},{"key":"S1047951125001763_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.04.045"},{"key":"S1047951125001763_ref16","doi-asserted-by":"publisher","DOI":"10.5339\/gcsp.2015.23"},{"key":"S1047951125001763_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s40746-020-00209-0"},{"key":"S1047951125001763_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02844-0"},{"key":"S1047951125001763_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq520"},{"key":"S1047951125001763_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-016-0932-5"},{"key":"S1047951125001763_ref5","doi-asserted-by":"publisher","DOI":"10.1080\/10976640601187596"},{"key":"S1047951125001763_ref9","first-page":"e643","article-title":"Early european experience with the venus P-valve\u00ae: filling the gap in percutaneous pulmonary valve implantation","volume":"12","author":"Husain","year":"2016","journal-title":"EuroIntervention J Eur Collab Work Group Interv Cardiol Eur Soc Cardiol"},{"key":"S1047951125001763_ref15","first-page":"1131","article-title":"Early clinical experience with a novel self-expanding percutaneous stent-valve in the native right ventricular outflow tract: Venus P Valve for Rehabilitation of the RVOT in Patients with Chronic Severe PR","volume":"84","author":"Cao","year":"2014","journal-title":"Catheter Cardiovasc Interv"},{"key":"S1047951125001763_ref4","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00299"},{"key":"S1047951125001763_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.034"},{"key":"S1047951125001763_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.10.065"},{"key":"S1047951125001763_ref2","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1093\/eurheartj\/ehq249","article-title":"ESC Guidelines for the management of grown-up congenital heart disease (new version 2010): The Task Force on the Management of Grown-up Congenital Heart Disease of the European Society of Cardiology (ESC)","volume":"31","author":"Baumgartner","year":"2010","journal-title":"Eur Heart J"},{"key":"S1047951125001763_ref25","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.033239"},{"key":"S1047951125001763_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.05.034"},{"key":"S1047951125001763_ref34","first-page":"e016459","article-title":"Subclinical leaflet thrombosis after transcatheter pulmonary valve implantation: two clinical concerns","volume":"17","author":"Akazawa","year":"2024","journal-title":"Circ Cardiovasc Imaging [Internet]"},{"key":"S1047951125001763_ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.009707"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125001763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:17:42Z","timestamp":1781180262000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125001763\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1047951125001763"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125001763","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,13]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}