{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:59:31Z","timestamp":1781182771791,"version":"3.54.1"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Severe Ebstein\u2019s disease often necessitates early neonatal surgical intervention, although, in some patients, surgery may be delayed until infancy or later, and medical management may be undertaken instead. Various indicators, such as tricuspid regurgitation flow velocity, have been studied to predict single or biventricular circulation; however, indicators predicting the need for neonatal surgery have not been addressed. We aimed to identify predictive indices for neonatal surgical necessity by analysing the clinical characteristics of those requiring and not requiring neonatal surgery. We enrolled eight patients with severe Ebstein\u2019s disease who were born at our hospital from 2018 to 2023. Four patients underwent neonatal surgery (Group S), whereas four did not (Group F). We compared pregnancy, delivery, and postnatal clinical courses and laboratory indices before and after birth between the groups. The systolic\/diastolic time ratio, an index of ventricular function calculated from the TR waveform of echocardiography at birth, was significantly prolonged in Group S [2.18 \u00b1 0.31 vs. 1.72 \u00b1 0.20 in Group F (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.043)]. The area under the receiver operating characteristic curve was 0.94, with a threshold systolic\/diastolic time ratio value of 1.99 using Youden\u2019s method. This ratio predicted neonatal surgery necessity with 100% sensitivity and 75% specificity. Despite the small sample size, we demonstrated that the systolic\/diastolic time ratio is a valuable predictive index of ventricular function and prognosis in severe Ebstein\u2019s disease patients. A systolic\/diastolic time ratio &lt;2, determined from the tricuspid regurgitation waveform on echocardiography at birth, supports patient monitoring without surgical intervention through the newborn period and beyond.\n                  <\/jats:p>","DOI":"10.1017\/s1047951125001787","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T06:49:10Z","timestamp":1747118950000},"page":"1116-1120","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["A predictive index for the need for neonatal surgical intervention in severe Ebstein\u2019s disease"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-6860","authenticated-orcid":false,"given":"Shinichiro","family":"Sakaki","sequence":"first","affiliation":[{"name":"Kanagawa Children\u2019s Medical 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