{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:59:50Z","timestamp":1781182790812,"version":"3.54.1"},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hyperlactatemia is a common and concerning finding in the paediatric cardiac ICU as it may signify tissue hypoperfusion and\/or hypoxia. However, it is important to include other aetiologies for an elevated lactate in the differential, especially when the lactate is significantly elevated (&gt; 8 mmol\/L). We present the case of metabolic acidosis with severe hyperlactatemia secondary to Warburg effect and presumed thiamine deficiency in a paediatric heart transplant patient with post-transplant lymphoproliferative disorder.<\/jats:p>","DOI":"10.1017\/s1047951125001830","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T23:41:29Z","timestamp":1747784489000},"page":"1287-1289","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Severe hyperlactatemia from Warburg effect due to post-transplant lymphoproliferative disorder after paediatric heart transplantation with resolution following thiamine administration"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8794-7640","authenticated-orcid":false,"given":"Michael J.","family":"Martinez","sequence":"first","affiliation":[{"name":"NYU Grossman School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"St. Francis","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Contreras Yametti","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Biary","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh K.","family":"Singh","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"S1047951125001830_ref8","first-page":"5121032","article-title":"Thiamine deficiency leading to refractory lactic acidosis in a pediatric patient","volume":"2017","author":"Teagarden","year":"2017","journal-title":"Case Rep Crit Care"},{"key":"S1047951125001830_ref7","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.939008"},{"key":"S1047951125001830_ref4","first-page":"A 1958","article-title":"Lactic acidosis in a critically ill cancer patient: beware the Warburg effect","volume":"193","author":"Short","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"S1047951125001830_ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2023-259335"},{"key":"S1047951125001830_ref1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v12.i5.350"},{"key":"S1047951125001830_ref2","first-page":"132","article-title":"Lactic acidosis as presenting symptom of thiamine deficiency in children with hematologic malignancy","volume":"6","author":"Lerner","year":"2017","journal-title":"J Pediatr Intensive Care"},{"key":"S1047951125001830_ref5","first-page":"3704309","article-title":"Unusual case of severe lactic acidosis in a liver transplant patient","volume":"2017","author":"Golhar","year":"2017","journal-title":"Case Rep Transplant"},{"key":"S1047951125001830_ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00376-4"},{"key":"S1047951125001830_ref6","first-page":"307","article-title":"Severe lactic acidosis in a critically ill child: think about thiamine! a case report","volume":"10","author":"Didisheim","year":"2020","journal-title":"J Pediatr Intensive Care"},{"key":"S1047951125001830_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002074"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125001830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:16:55Z","timestamp":1781180215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125001830\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1047951125001830"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125001830","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,21]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}