{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:37:17Z","timestamp":1788907037339,"version":"build-2803163510"},"reference-count":120,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"unspecified","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S104795112500191X_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Kawasaki disease is a systemic vasculitis that primarily affects young children and represents a major cause of acquired heart disease in children in developed countries. The incidence of Kawasaki disease exhibits significant global variation, and the worldwide burden remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S104795112500191X_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A systematic review was conducted to investigate the global incidence of Kawasaki disease in children under 5 years of age. A comprehensive literature search was performed in PubMed, Embase, and KoreaMed up to July 15, 2024. Studies reporting population-level Kawasaki disease incidence were included. Data extraction and quality assessment were performed independently by two reviewers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S104795112500191X_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The search yielded 3,197 articles, of which 105 met the inclusion criteria. These studies examined Kawasaki disease incidence in children under 5 years of age across 34 countries, with the majority focusing on the Western Pacific Region and the Region of the Americas. The results demonstrated a wide range of Kawasaki disease incidence globally, with significant geographic variations. The highest incidence rates were observed in Japan, Korea, and Taiwan, with a trend of gradual increase over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S104795112500191X_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study represents the most comprehensive review of global Kawasaki disease incidence to date. The substantial variation in incidence underscores the need to understand the factors influencing regional differences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s104795112500191x","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T03:06:48Z","timestamp":1746673608000},"page":"1028-1039","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":16,"title":["Global incidence of Kawasaki disease: a systematic review"],"prefix":"10.1017","volume":"35","author":[{"given":"Cho Ryok","family":"Kang","sequence":"first","affiliation":[{"name":"Korea University College of Medicine"},{"name":"Wonkwang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue Seong","family":"Lee","sequence":"additional","affiliation":[{"name":"Korea University College of Medicine"},{"name":"Korea University College of Medicine and Korea University Anam 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