{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:07:00Z","timestamp":1793898420887,"version":"4.8.0"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"unspecified","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125100814_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Ventricular tachycardia is a rare condition in the fetus and neonate with a paucity of data regarding the management and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125100814_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We reviewed the clinical histories, associated CHD and syndromes, diagnostic investigations, management strategies, and outcomes for all fetuses and neonates with ventricular tachycardia encountered between 2005 and 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125100814_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Five fetal and 8 neonatal cases of ventricular tachycardia were encountered. Two (40%) fetal cases, compared to 5 (62%) neonatal cases had CHD (p = 0.59), and only 1 fetus had cardiomyopathy with findings suggesting restriction before ventricular tachycardia onset. The median age at ventricular tachycardia presentation was 32 (26\u201337) weeks for fetal and 11\u00a0(1\u201327) days for neonatal cases. Of the fetal cases, 2 were initially treated trans-placentally with propranolol and 2 with amiodarone. Two fetuses (40%) had ventricular tachycardia suppression prenatally that recurred during the neonatal period necessitating propranolol therapy, 2 (40%) had resolution before birth with no postnatal recurrence, and the cardiomyopathy case never achieved full control, developed hydrops and demised. Of the neonatal cases, 4 received intravenous antiarrhythmics on admission: 3 amiodarone and 1 esmolol, and 2 of these were converted to propranolol and 2 to sotalol. Three other neonates initially received propranolol, with 1 discharged on propranolol, 1 on sotalol, and 1 on mexiletine after failed propranolol and sotalol treatment. The 8th neonate was discharged on no medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125100814_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Most fetal and neonatal ventricular tachycardia is manageable with pharmacologic therapy. Given its rarity, larger studies are needed to identify optimal management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125100814","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T01:33:07Z","timestamp":1751247187000},"page":"1184-1188","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Ventricular tachycardia in fetus and neonate: a single centre experience"],"prefix":"10.1017","volume":"35","author":[{"given":"Lisa","family":"Hornberger","sequence":"first","affiliation":[{"name":"University of Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Escudero","sequence":"additional","affiliation":[{"name":"University of Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1485-8369","authenticated-orcid":false,"given":"Hilal","family":"Al Riyami","sequence":"additional","affiliation":[{"name":"Sultan Qaboos University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"S1047951125100814_ref5","first-page":"423","volume-title":"Textbook of Fetal Cardiology","author":"Simpson","year":"2000"},{"key":"S1047951125100814_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/BF02505212"},{"key":"S1047951125100814_ref16","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.049049"},{"key":"S1047951125100814_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12155"},{"key":"S1047951125100814_ref18","first-page":"1372","article-title":"Long-term outcome in fetuses with cardiac arrhythmias","volume":"102","author":"Boldt","year":"2003","journal-title":"Obstet 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}