{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:59:31Z","timestamp":1781182771816,"version":"3.54.1"},"reference-count":46,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"unspecified","delay-in-days":53,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125100887_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Persistent pulmonary hypertension of the newborn is a serious disease with significant morbidity and mortality. Magnesium sulphate has been proposed as a potential treatment for persistent pulmonary hypertension of the newborn, but its efficacy remains unclear. The article aims to evaluate the effects of magnesium sulphate on persistent pulmonary hypertension of the newborn.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125100887_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A comprehensive search of PubMed, Web of Science, Embase, and Cochrane Library was conducted to identify relevant studies. The primary outcomes were pulmonary artery pressure and oxygenation index, while secondary outcomes included mean blood pressure, alveolar-arterial oxygen difference, arterial partial pressure of oxygen (PaO\n                      <jats:sub>2<\/jats:sub>\n                      ), arterial partial pressure of carbon dioxide (PaCO\n                      <jats:sub>2<\/jats:sub>\n                      ), and arterial oxygen saturation. Statistical analysis was performed by Cochrane Review Manager 5.3.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125100887_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study analysed twelve studies involving 380 patients. Results indicated that magnesium sulphate treatment significantly reduced pulmonary artery pressure levels (MD \u221224.96, 95% CI \u221228.19 to \u221221.73,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) and mean blood pressure (MD \u22123.11, 95% CI \u22123.91 to \u22122.32,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) compared to pretreatment. Additionally, it led to a notable decrease in oxygenation index (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.00001) and alveolar-arterial oxygen difference (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001), while increasing PaO\n                      <jats:sub>2<\/jats:sub>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) and arterial oxygen saturation (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). However, there was no significant effect on PaCO\n                      <jats:sub>2<\/jats:sub>\n                      levels compared to pretreatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125100887_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Magnesium sulphate is a valuable therapy for persistent pulmonary hypertension of the newborn. It markedly reduced pulmonary artery pressure, alveolar-arterial oxygen difference, and oxygenation index, while enhancing PaO\n                      <jats:sub>2<\/jats:sub>\n                      , and arterial oxygen saturation, with no impact on PaCO\n                      <jats:sub>2<\/jats:sub>\n                      levels. Magnesium sulphate may also reduce mean blood pressure following a 2-hour treatment. Additional studies are necessary to further clarify its efficacy and potential side effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125100887_as5\">\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>This study was registered with PROSPERO (CRD42024578092).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125100887","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T03:30:26Z","timestamp":1753327826000},"page":"1225-1232","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Effect of magnesium sulphate on persistent pulmonary hypertension of the newborn: a systematic review and meta-analysis"],"prefix":"10.1017","volume":"35","author":[{"given":"Zhe","family":"Tang","sequence":"first","affiliation":[{"name":"Capital Medical 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