{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:03:14Z","timestamp":1770742994876,"version":"3.49.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Some of us recently discussed the problems existing in describing the channels that permit interventricular shunting. We offered suggestions for improvement, particularly when assessing the channel that is found when both arterial trunks arise from the morphologically right ventricle. Our proposals engendered significant debate, with several criticisms appearing in an editorial commentary. The commentator now accepts that not all of the criticisms were justified. In an attempt to seek further consensus, we have now joined with additional colleagues so as to clarify the aspects of our initial work that created potential confusion. Having reviewed the aspects producing the misconceptions, we again provide an overview of the evidence relevant to deficient ventricular septation now provided by knowledge of cardiac development. We show how remodelling of the primary interventricular communication involves the provision of an inlet for the developing right ventricle and an outlet for the developing right ventricle. During this process, the secondary interventricular foramen, which is a subaortic-left ventricular communication when the outflow tract remains supported exclusively by the right ventricle, becomes the outflow tract for the left ventricle, with a subaortic-right ventricular communication then being closed to complete ventricular septation. We show how knowledge of these processes, coupled with an appreciation of the mechanism of formation of the muscular ventricular septum and the separate formation of an embryonic muscular outlet septum, which with normal development becomes the subpulmonary infundibulum, provides the basis for understanding the various phenotypic lesions that permit interventricular shunting in the postnatal heart.<\/jats:p>","DOI":"10.1017\/s104795112510139x","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T08:00:49Z","timestamp":1754899249000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Reaching consensus as to how knowledge of development underscores our understanding of deficient ventricular septation"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-9021","authenticated-orcid":false,"given":"Robert H.","family":"Anderson","sequence":"first","affiliation":[{"name":"Newcastle University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4024-8599","authenticated-orcid":false,"given":"Lucile","family":"Houyel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Lopez","sequence":"additional","affiliation":[{"name":"Stanford University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-8304","authenticated-orcid":false,"given":"Niraj N.","family":"Pandey","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane E.","family":"Spicer","sequence":"additional","affiliation":[{"name":"Johns Hopkins All Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.","family":"Cook","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, Zayed Center for Rare Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-9338","authenticated-orcid":false,"given":"Colin J.","family":"McMahon","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Ireland at Crumlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4343-0951","authenticated-orcid":false,"given":"R. Krishna","family":"Kumar","sequence":"additional","affiliation":[{"name":"Amrita Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Crucean","sequence":"additional","affiliation":[{"name":"Birmingham Childen\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8926-3752","authenticated-orcid":false,"given":"Justin T.","family":"Tretter","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Children\u2019s"},{"name":"Heart, Vascular, & Thoracic Institute, Cleveland Clinic Foundation"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"S104795112510139X_ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-019-1044-2"},{"key":"S104795112510139X_ref16","first-page":"77","article-title":"Contribution a l\u2019anatomie pathologique de la maladie bleue (cyanose cardiaque)","volume":"25","author":"Fallot","year":"1888","journal-title":"Marseille Med"},{"key":"S104795112510139X_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.08.040"},{"key":"S104795112510139X_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90803-1"},{"key":"S104795112510139X_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezaa378"},{"key":"S104795112510139X_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.12.003"},{"key":"S104795112510139X_ref15","first-page":"516","article-title":"The surgical significance of phenotypic variability in the setting of tetralogy of Fallot","volume":"16","author":"Chowdhury","year":"2025","journal-title":"World J Ped Card Surg"},{"key":"S104795112510139X_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(79)90178-4"},{"key":"S104795112510139X_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S104795112100281X"},{"key":"S104795112510139X_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjcpc.2023.09.003"},{"key":"S104795112510139X_ref18","doi-asserted-by":"publisher","DOI":"10.1111\/joa.13973"},{"key":"S104795112510139X_ref19","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd6010009"},{"key":"S104795112510139X_ref5","first-page":"24","article-title":"The Taussig-Bing heart: qualitative and quantitative anatomy","volume":"81","author":"Lev","year":"1966","journal-title":"Arch Pathol"},{"key":"S104795112510139X_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.06.020"},{"key":"S104795112510139X_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)36385-8"},{"key":"S104795112510139X_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)01247-3"},{"key":"S104795112510139X_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.03.049"},{"key":"S104795112510139X_ref1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951123003943"},{"key":"S104795112510139X_ref21","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00006.2003"},{"key":"S104795112510139X_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy474"},{"key":"S104795112510139X_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(78)90828-7"},{"key":"S104795112510139X_ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S104795112400060X"},{"key":"S104795112510139X_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.07.054"},{"key":"S104795112510139X_ref22","first-page":"408","article-title":"Excessive trabeculation of the left ventricle","volume":"16","author":"Petersen","year":"2023","journal-title":"JACC: Cardiovasc Imag"},{"key":"S104795112510139X_ref20","doi-asserted-by":"publisher","DOI":"10.1002\/ar.24020"},{"key":"S104795112510139X_ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1024053"},{"key":"S104795112510139X_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(49)91133-3"},{"key":"S104795112510139X_ref28","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezad423"},{"key":"S104795112510139X_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(86)90114-2"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S104795112510139X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T08:00:50Z","timestamp":1754899250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S104795112510139X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":29,"alternative-id":["S104795112510139X"],"URL":"https:\/\/doi.org\/10.1017\/s104795112510139x","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}