{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:19:00Z","timestamp":1755796740049,"version":"3.44.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S104795112510142X_as1\">\n\t    <jats:title>Objective:<\/jats:title>\n\t    <jats:p>Congenitally corrected transposition of the great arteries is a rare congenital cardiac condition with varied presentations, complicating treatment decisions. This study evaluates the impact of medical management, physiologic repair, and anatomic repair on health-related quality of life.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S104795112510142X_as2\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>A cross-sectional follow-up was conducted on 50 congenitally corrected transposition of the great arteries patients from a cohort of 240 at Cleveland Clinic (1995-2020). Health-related quality of life was assessed using MacNew and PROMIS-10 questionnaires. Echocardiographic data on systemic atrioventricular valvular regurgitation and systemic ventricular dysfunction were analysed. A time-varying coefficient model evaluated these factors\u2019 impact on health-related quality of life.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S104795112510142X_as3\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>Anatomic repair had significantly higher PROMIS-10 Physical T-scores compared to physiologic repair (median 50.9 vs 41.6, <jats:italic>p<\/jats:italic> = 0.04). MacNew Social scores were significantly higher for medical management compared to physiologic repair (median 6.8 vs 6.0, <jats:italic>p<\/jats:italic> = 0.02). Echocardiographic analysis revealed that systemic ventricular dysfunction had a stronger immediate impact on health-related quality of life. Systemic atrioventricular valve regurgitation showed a delayed negative effect, significant at 6-10 years after echo, although this effect gradually decreased over time. Anatomic repair patients had better systemic ventricular function (84.6% normal), and less systemic atrioventricular valve regurgitation (69.2% had none) compared to medical management and physiologic repair groups.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S104795112510142X_as4\">\n\t    <jats:title>Conclusions:<\/jats:title>\n\t    <jats:p>Anatomic repair improves health-related quality of life in congenitally corrected transposition of the great arteries patients, with physiologic repair showing some gains over time. Health-related quality of life data should provide important guidance regarding treatment decisions, especially in well-balanced congenitally corrected transposition of the great arteries patients.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s104795112510142x","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T08:22:53Z","timestamp":1755505373000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Health-related quality of life outcomes for congenitally corrected transposition of the great arteries patients across the therapeutic spectrum"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0254-1069","authenticated-orcid":false,"given":"Anish R.","family":"Katta","sequence":"first","affiliation":[{"name":"University Program"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivni","family":"Patel","sequence":"additional","affiliation":[{"name":"University Program"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miza S.","family":"Hammoud","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amol","family":"Pande","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Toth","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel M.","family":"Hoenig","sequence":"additional","affiliation":[{"name":"University Program"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4062-7584","authenticated-orcid":false,"given":"Yibei","family":"Zhu","sequence":"additional","affiliation":[{"name":"University Program"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chin","sequence":"additional","affiliation":[{"name":"University Program"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashed","family":"Mahboubi","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin A.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Karamlou","sequence":"additional","affiliation":[{"name":"Akron Children\u2019s Hospital"},{"name":"Cincinnati Children\u2019s Hospital Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The ccTGA working group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"doi-asserted-by":"publisher","key":"S104795112510142X_ref16","DOI":"10.1016\/j.jtcvs.2020.11.164"},{"doi-asserted-by":"publisher","key":"S104795112510142X_ref18","DOI":"10.1016\/0197-2456(89)90005-6"},{"doi-asserted-by":"publisher","key":"S104795112510142X_ref11","DOI":"10.1016\/S0022-5223(19)38539-3"},{"doi-asserted-by":"publisher","key":"S104795112510142X_ref3","DOI":"10.1056\/NEJM197005072821912"},{"doi-asserted-by":"publisher","key":"S104795112510142X_ref4","DOI":"10.1097\/HCO.0000000000001052"},{"doi-asserted-by":"publisher","key":"S104795112510142X_ref28","DOI":"10.1016\/j.jtcvs.2011.08.031"},{"doi-asserted-by":"publisher","key":"S104795112510142X_ref25","DOI":"10.4081\/hpr.2013.932"},{"unstructured":"22. 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